In the context of tumor suppression, p53 is an undisputedly critical protein. Functioning
primarily as a transcription factor, p53 helps fend off the initiation and progression of tumors …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

Pancreatic beta cell death is a hallmark of type 1 (T1D) and type 2 (T2D) diabetes, but the
molecular mechanisms underlying this aspect of diabetic pathology are poorly understood …

Aggressive cancers often have activating mutations in growth-controlling oncogenes and
inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the …

The protein tyrosine phosphatase family (PTP) contains a group of dual-specificity
phosphatases (DUSPs) that regulate the activivity of MAP kinases (MAPKs), which are key …

MicroRNAs (miRNAs) are noncoding RNAs of~ 22 nucleotides that regulate gene
expression post-transcriptionally by binding to the 3′ untranslated region of messenger …

Non-small-cell lung cancer (NSCLC) is one of the most commonly diagnosed cancers
worldwide with limited effective therapies. Cisplatin (DDP), as the first-line treatment, is …

DNA double-strand breaks (DSBs) are the most lethal DNA damages which lead to severe
genome instability. Phosphorylation is one of the most important protein post-translation …

Abstract Adenylate kinase 2 (AK2), which balances adenine nucleotide pool, is a multi-
functional protein. Here we show that AK2 negatively regulates tumour cell growth. AK2 …

Background Poly (ADP‐ribose) polymerase (PARP) signals DNA damage and facilitates
DNA repair. PARP inhibitors are being evaluated in cancers with defective DNA repair …