Shankopathies in the developing brain in autism spectrum disorders
The SHANK family of proteins play critical structural and functional roles in the postsynaptic
density (PSD) at excitatory glutamatergic synapses. Through their multidomain structure they …
density (PSD) at excitatory glutamatergic synapses. Through their multidomain structure they …
Autism-associated Shank3 is essential for homeostatic compensation in rodent V1
V Tatavarty, AT Pacheco, CG Kuhnle, H Lin… - Neuron, 2020 - cell.com
Mutations in Shank3 are strongly associated with autism spectrum disorders and neural
circuit changes in several brain areas, but the cellular mechanisms that underlie these …
circuit changes in several brain areas, but the cellular mechanisms that underlie these …
Embryonic exposure to environmental factors drives transmitter switching in the neonatal mouse cortex causing autistic-like adult behavior
Autism spectrum disorders (ASD) can be caused by environmental factors. These factors act
early in the development of the nervous system and induce stereotyped repetitive behaviors …
early in the development of the nervous system and induce stereotyped repetitive behaviors …
Swimming exercise is a promising early intervention for autism‐like behavior in Shank3 deletion rats
D Xu, Y Meng, S An, W Meng, H Li… - CNS Neuroscience …, 2023 - Wiley Online Library
Introduction SHANK3 is an important excitatory postsynaptic scaffold protein, and its
mutations lead to genetic cause of neurodevelopmental diseases including autism spectrum …
mutations lead to genetic cause of neurodevelopmental diseases including autism spectrum …
Rôle des Méninges et des Péricytes dérivés de la Crête Neurale dans les Altérations Cognitives à la Naissance
E Bruet - 2023 - theses.hal.science
The neural crest is an embryonic multipotent cell population deriving from the neurectoderm
during the neurulation. These cells migrate to colonize the embryonic body and generate …
during the neurulation. These cells migrate to colonize the embryonic body and generate …
Dr. Sprengers et al. Reply.
JJ Sprengers, DM van Andel… - Journal of the American …, 2021 - europepmc.org
Before we elaborate on the postulated discrepancies between our trial and previous
bumetanide in autism spectrum disorder (ASD) trials, we would like to acknowledge the …
bumetanide in autism spectrum disorder (ASD) trials, we would like to acknowledge the …
Glutamate-based preclinical and clinical dysfunction and treatment in bipolar disorder
Glutamate is the major excitatory amino acid neurotransmitter in the brain, with~ 50% of
neurons using it as their primary neurotransmitter. Glutamate dynamics also involves an …
neurons using it as their primary neurotransmitter. Glutamate dynamics also involves an …