M Katan, S Cockcroft - Essays in biochemistry, 2020 - portlandpress.com
Abstract Phosphatidylinositol (4, 5) bisphosphate (PI (4, 5) P2) has become a major focus in biochemistry, cell biology and physiology owing to its diverse functions at the plasma …
N Borregaard, JB Cowland - … Journal of the American Society of …, 1997 - ashpublications.org
Fig 2. Classification of granules in neutrophils. Peroxidase-positive (azurophilic or primary) granules are characterized by the content of MPO and may be further divided based on their …
Growing evidence suggests that phosphoinositides play an important role in membrane traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was identified as a major …
RD Burgoyne, A Morgan - Physiological reviews, 2003 - journals.physiology.org
Regulated exocytosis of secretory granules or dense-core granules has been examined in many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …
TO Chan, SE Rittenhouse… - Annual review of …, 1999 - annualreviews.org
▪ Abstract The protein kinase Akt/PKB is activated via a multistep process by a variety of signals. In the early steps of this process, PI-3 kinase-generated D3-phosphorylated …
A Honda, M Nogami, T Yokozeki, M Yamazaki… - Cell, 1999 - cell.com
Abstract Synthesis of phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2], a signaling phospholipid, is primarily carried out by phosphatidylinositol 4-phosphate 5-kinase [PI (4) …
ER Chapman - Annu. Rev. Biochem., 2008 - annualreviews.org
Neurotransmitter release at synapses involves a highly specialized form of membrane fusion that is triggered by Ca2+ ions and is optimized for speed. These observations were …
Insulin is produced by pancreatic β-cells, and once released to the blood, the hormone stimulates glucose uptake and suppresses glucose production. Defects in both the …
I Van den Bout, N Divecha - Journal of cell science, 2009 - journals.biologists.com
It has long been known that phosphoinositides are present in cellular membranes, but only in the past four decades has our understanding of their importance for proper cell function …