Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Abstract Phosphatidylinositol (4, 5) bisphosphate (PI (4, 5) P2) has become a major focus in
biochemistry, cell biology and physiology owing to its diverse functions at the plasma …

Fig 2. Classification of granules in neutrophils. Peroxidase-positive (azurophilic or primary)
granules are characterized by the content of MPO and may be further divided based on their …

Growing evidence suggests that phosphoinositides play an important role in membrane
traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was identified as a major …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

▪ Abstract The protein kinase Akt/PKB is activated via a multistep process by a variety of
signals. In the early steps of this process, PI-3 kinase-generated D3-phosphorylated …

Abstract Synthesis of phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2], a signaling
phospholipid, is primarily carried out by phosphatidylinositol 4-phosphate 5-kinase [PI (4) …

Neurotransmitter release at synapses involves a highly specialized form of membrane fusion
that is triggered by Ca2+ ions and is optimized for speed. These observations were …

Insulin is produced by pancreatic β-cells, and once released to the blood, the hormone
stimulates glucose uptake and suppresses glucose production. Defects in both the …

It has long been known that phosphoinositides are present in cellular membranes, but only
in the past four decades has our understanding of their importance for proper cell function …