Chronological age represents the single greatest risk factor for human disease. One
plausible explanation for this correlation is that mechanisms that drive ageing might also …

Uncontrolled cellular proliferation, mediated by dysregulation of the cell-cycle machinery
and activation of cyclin-dependent kinases (CDKs) to promote cell-cycle progression, lies at …

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To
identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes …

Increased levels of DNA fragments have frequently been found in the blood plasma of
cancer patients. Published data suggest that only a fraction of the DNA in blood plasma is …

Pathology and Genetics of Head and Neck Tumoursis the latest volume in the new WHO
series, on histological and genetic typing of human tumours. This authoritative, concise …

Two genes are synthetic lethal if mutation of either alone is compatible with viability but
mutation of both leads to death. So, targeting a gene that is synthetic lethal to a cancer …

Abstract Renal Cell Carcinoma (RCC) has the highest mortality rate of the genitourinary
cancers and the incidence of RCC has risen steadily. If detected early, RCC is curable by …

Head and neck cancers include neoplasms of the oral cavity, pharynx, and larynx. The risk
of these cancers is strongly associated with smoking and alcohol ingestion. There have …

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

The cell cycle inhibitor p16 INK4a is inactivated in many human tumors and in families with
hereditary melanoma and pancreatic cancer. Tumor-associated alterations in the INK4a …