In humans, various genetic defects or age-related diseases, such as diabetic retinopathies,
glaucoma, and macular degeneration, cause the death of retinal neurons and profound …

Müller glia originate from neuroepithelium and are the principal glial cells in the retina.
During retinal development, Müller glia are one of the last cell types to be born. In lower …

Recent studies suggest midkine (MDK) is involved in the development and regeneration of
the zebrafish retina. We investigate the expression patterns of MDK and related factors, roles …

To identify candidate tissue regeneration enhancer elements (TREEs) important for
zebrafish fin regeneration, we performed ATAC-seq from bulk tissue or purified fibroblasts of …

The ability to regenerate tissues varies between species and between tissues within a
species. Mammals have a limited ability to regenerate tissues, whereas zebrafish possess …

In fishes and salamanders, but not mammals, neural stem cells switch back to neurogenesis
after injury. The signalling environment of neural stem cells is strongly altered by the …

Neuronal degeneration in the zebrafish retina stimulates Müller glia (MG) to proliferate and
generate multipotent progenitors for retinal repair. Controlling this proliferation is critical to …

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for
neuron restoration therapies. Using lessons from regenerative species, we have developed …

We summarize recent findings in different animal models regarding the different cell‐
signaling pathways and gene networks that influence the reprogramming of Müller glia into …

Photoreceptor degeneration leads to irreversible vision loss in humans with retinal
dystrophies such as retinitis pigmentosa. Whereas photoreceptor loss is permanent in …