Respiratory epithelial cell responses to SARS-CoV-2 in COVID-19
JP Bridges, EK Vladar, H Huang, RJ Mason - Thorax, 2022 - thorax.bmj.com
COVID-19 has different clinical stages, and effective therapy depends on the location and
extent of the infection. The purpose of this review is to provide a background for …
extent of the infection. The purpose of this review is to provide a background for …
COVID-19 and the vasculature: current aspects and long-term consequences
B Martinez-Salazar, M Holwerda, C Stuedle… - Frontiers in cell and …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first identified in
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19)
pandemic has caused millions of deaths worldwide. Genome-wide association studies …
pandemic has caused millions of deaths worldwide. Genome-wide association studies …
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection
SB Biering, SA Sarnik, E Wang, JR Zengel, SR Leist… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
[HTML][HTML] SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming
How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …
nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we …
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2
Y Gu, J Cao, X Zhang, H Gao, Y Wang, J Wang, J He… - Cell research, 2022 - nature.com
Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.
However, little is known about SARS-CoV-2 host receptors with the exception of ACE2 …
However, little is known about SARS-CoV-2 host receptors with the exception of ACE2 …
Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics
NR Cheemarla, TA Watkins, VT Mihaylova… - Journal of Experimental …, 2021 - rupress.org
Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish
infection, and the replication level correlates with the likelihood of viral transmission. Here …
infection, and the replication level correlates with the likelihood of viral transmission. Here …
SARS-CoV-2 spike protein 1 activates microvascular endothelial cells and complement system leading to platelet aggregation
Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus
disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability …
disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability …
An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo
Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but
emergence of viral variants that are antigenically distinct from the vaccine strains are of …
emergence of viral variants that are antigenically distinct from the vaccine strains are of …