Advancing biologic therapy for refractory autoimmune hepatitis

AJ Czaja - Digestive Diseases and Sciences, 2022 - Springer
Biologic agents may satisfy an unmet clinical need for treatment of refractory autoimmune
hepatitis. The goals of this review are to present the types and results of biologic therapy for …

Autoimmune Hepatitis: Pathophysiology

Z Yuming, T Ruqi, ME Gershwin… - Clinics in Liver …, 2024 - liver.theclinics.com
Autoimmune hepatitis (AIH) is a chronic inflammatory disease of the liver, characterized by
elevated transaminase, high circulating immunoglobin G levels, presence of autoantibodies …

Exploring the pathogenic role and therapeutic implications of interleukin 2 in autoimmune hepatitis

AJ Czaja - Digestive Diseases and Sciences, 2021 - Springer
Interleukin 2 is essential for the expansion of regulatory T cells, and low-dose recombinant
interleukin 2 has improved the clinical manifestations of diverse autoimmune diseases in …

Precision medicine for autoimmune hepatitis

RL Chen, QX Wang, X Ma - Journal of Digestive Diseases, 2019 - Wiley Online Library
Autoimmune hepatitis (AIH) is an autoimmune liver disease induced by environmental
factors in genetically susceptible individuals. AIH is characterized by …

Association study between vitiligo and autoimmune‐related genes CYP27B1, REL, TNFAIP3, IL2 and IL21

LT Martins, HR Frigeri, CCS de Castro… - Experimental …, 2020 - Wiley Online Library
The aetiology of vitiligo has not been fully elucidated, and several hypotheses have been
investigated; among them, the most explored assumes an autoimmune basis for the …

Immunogenicity and safety of HBAI20 hepatitis B vaccine in non‐responders: double‐blinded, randomised, controlled phase 2 trial

ÖM Koc, P De Smedt, C Kremer, G Robaeys… - Liver …, 2021 - Wiley Online Library
Abstract Background & Aims Approximately 5%–10% of the general population respond
inadequately to licensed recombinant hepatitis B vaccines. We assessed the …

[HTML][HTML] Analysis of prognostic germline polymorphisms in patients with advanced hepatocellular carcinoma

M Herman, BH Lok, S Gallinger, L Dawson… - Translational …, 2023 - ncbi.nlm.nih.gov
Background The prognosis of hepatocellular carcinoma (HCC) is influenced by both tumor
and patient specific factors. Current therapies of advanced HCC target angiogenesis and …

Genetic polymorphisms of regulatory T cell‐related genes modulate systemic inflammation induced by viral hepatitis

HH Kao, RL Yu, WL Chuang, JF Huang… - … Journal of Medical …, 2021 - Wiley Online Library
Viral hepatitis is a devastating disease with the risk for cirrhosis and carcinogenicity.
Regulatory T cells (Tregs) play important roles in the disease course of viral hepatitis via …

Association of Interleukin-2 Gene Polymorphism with Henoch-schönlein Purpura Nephritis

J Cao, J Zhang, H Xu, W Li, J Shi, Q Ye - Iranian Journal of Allergy …, 2023 - ijaai.tums.ac.ir
Henoch-Schönlein purpura nephritis (HSPN) is a common vasculitis that mostly affects
children, and previous studies have indicated that genetic factors may influence disease …

Genetic predictors of cytokine response in ENT-associated encephalitis

VV Kravtsov, NA Shnayder, NG Neznanov… - Personalized Psychiatry …, 2021 - jppn.ru
Introduction: An imbalance of the genetically determined cytokine response plays a key role
in the etiology of ENT-associated encephalitis. In recent years, an attempt has been made to …