The X-linked gene Rlim plays major roles in female mouse development and reproduction,
where it is crucial for the maintenance of imprinted X chromosome inactivation in …

Radiotherapy is an important modality for the local control of human cancers, but the
radioresistance induced by aberrant apoptotic signaling is a hallmark of cancers. Restoring …

Porcine reproductive and respiratory syndrome virus (PRRSV) can potently suppress type I
interferon production and escape from innate immune responses. PRRSV nonstructural …

Protein ubiquitylation regulates key biological processes including transcription. This is
exemplified by the E3 ubiquitin ligase RNF12/RLIM, which controls developmental gene …

RLIM/Rnf12 is an E3 ubiquitin ligase that has originally been identified as a transcriptional
cofactor associated with LIM domain transcription factors. Indeed, this protein modulates …

Background. RNF12 has been linked to a variety of biological activities, including the control
of the MDM2/P53 pathway, although its additional functions remain unclear. RNF12 was …

Ubiquitylation enzymes are involved in all aspects of eukaryotic biology and are frequently
disrupted in disease. One example is the E3 ubiquitin ligase RNF12/RLIM, which is mutated …

Interpretation of the significance of maternally inherited X chromosome variants in males
with neurocognitive phenotypes continues to present a challenge to clinical geneticists and …

MAF1 homolog, negative regulator of RNA polymerase III (MAF1) is a key repressor of RNA
polymerase (pol) III–dependent transcription and functions as a tumor suppressor. Its …

The E3 ubiquitin ligase RNF12/RLIM controls developmental gene expression and is
mutated in the X-linked intellectual disability disorder Tonne-Kalscheuer syndrome …