An overview of biotransformation and toxicity of diterpenes

IP De Sousa, MV Sousa Teixeira… - Molecules, 2018 - mdpi.com
Diterpenes have been identified as active compounds in several medicinal plants showing
remarkable biological activities, and some isolated diterpenes are produced at commercial …

Recent developments in the fungal transformation of steroids

N Nassiri-Koopaei, MA Faramarzi - Biocatalysis and …, 2015 - Taylor & Francis
Steroids constitute a vital part of the active ingredients in pharmaceuticals and intermediates
used to produce medicines, and their application in chemical and agrochemical fields is also …

Small molecule inhibitors targeting activator protein 1 (AP-1) miniperspective

N Ye, Y Ding, C Wild, Q Shen… - Journal of medicinal …, 2014 - ACS Publications
Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of
cellular processes including proliferation, apoptosis, differentiation, survival, cell migration …

Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity

FB Mullauer, L van Bloois, JB Daalhuisen… - Anti-cancer …, 2011 - journals.lww.com
Betulinic acid (BetA) is a plant-derived pentacyclic triterpenoid with potent anticancer
capacity that targets the mitochondrial pathway of apoptosis. BetA has a broad efficacy in …

Bioactive molecules from Nocardia: diversity, bioactivities and biosynthesis

D Dhakal, V Rayamajhi, R Mishra… - Journal of Industrial …, 2019 - academic.oup.com
Nocardia spp. are catalase positive, aerobic, and non-motile Gram-positive filamentous
bacteria. Many Nocarida spp. have been reported as unusual causes of diverse clinical …

Microbial biotransformation to obtain new antifungals

LF Bianchini, MFC Arruda, SR Vieira… - Frontiers in …, 2015 - frontiersin.org
Antifungal drugs belong to few chemical groups and such low diversity limits the therapeutic
choices. The urgent need of innovative options has pushed researchers to search new …

[HTML][HTML] Emerging technologies for metabolite generation and structural diversification

KP Cusack, HF Koolman, UEW Lange… - Bioorganic & medicinal …, 2013 - Elsevier
Multiple technologies have emerged for structural diversification and efficient production of
metabolites of drug molecules. These include expanded use of enzymatic and bioorganic …

Recent advances in biotransformation by Cunninghamella species

MD Gonçalves, F Tomiotto-Pellissier… - Current Drug …, 2021 - ingentaconnect.com
The goal of the biotransformation process is to develop structural changes and generate
new chemical compounds, which can occur naturally in mammalian and microbial …

Inhibition of topoisomerase I activity and efflux drug transporters' expression by xanthohumol from hops

SH Lee, HJ Kim, JS Lee, IS Lee, BY Kang - Archives of pharmacal …, 2007 - Springer
Xanthohumol (XN) and its related compounds were evaluated for their cytotoxicity against
four different human cancer cell lines, A549 (lung), SK-OV-3 (ovarian), SK-MEL-2 …

Microbial biotransformation: a tool for drug designing

I Pervaiz, S Ahmad, MA Madni, H Ahmad… - Applied biochemistry and …, 2013 - Springer
For centuries microbial biotransformation has proved to be an imperative tool in alleviating
the production of various chemicals used in food, pharmaceutical, agrochemical and other …