Cortico-striatal-thalamic loop circuits of the salience network: a central pathway in psychiatric disease and treatment

SK Peters, K Dunlop, J Downar - Frontiers in systems neuroscience, 2016 - frontiersin.org
The salience network (SN) plays a central role in cognitive control by integrating sensory
input to guide attention, attend to motivationally salient stimuli and recruit appropriate …

Integrative brain network and salience models of psychopathology and cognitive dysfunction in schizophrenia

V Menon, L Palaniyappan, K Supekar - Biological Psychiatry, 2023 - Elsevier
Brain network models of cognitive control are central to advancing our understanding of
psychopathology and cognitive dysfunction in schizophrenia. This review examines the role …

Dysregulated brain dynamics in a triple-network saliency model of schizophrenia and its relation to psychosis

K Supekar, W Cai, R Krishnadas, L Palaniyappan… - Biological …, 2019 - Elsevier
Background Schizophrenia is a highly disabling psychiatric disorder characterized by a
range of positive “psychosis” symptoms. However, the neurobiology of psychosis and …

Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

A Segal, L Parkes, K Aquino, SM Kia, T Wolfers… - Nature …, 2023 - nature.com
The substantial individual heterogeneity that characterizes people with mental illness is
often ignored by classical case–control research, which relies on group mean comparisons …

Abnormalities of intrinsic regional brain activity in first-episode and chronic schizophrenia: a meta-analysis of resting-state functional MRI

J Gong, J Wang, X Luo, G Chen, H Huang… - Journal of psychiatry and …, 2020 - jpn.ca
Background: Resting-state functional MRI (fMRI) studies have provided much evidence for
abnormal intrinsic brain activity in schizophrenia, but results have been inconsistent …

[HTML][HTML] Dynamic functional connectivity in schizophrenia and bipolar disorder: A review of the evidence and associations with psychopathological features

G Cattarinussi, A Di Giorgio, F Moretti, E Bondi… - Progress in Neuro …, 2023 - Elsevier
Alterations of functional network connectivity have been implicated in the pathophysiology of
schizophrenia (SCZ) and bipolar disorder (BD). Recent studies also suggest that the …

Temporal variability of regional intrinsic neural activity in drug‐naïve patients with obsessive–compulsive disorder

J Liu, X Bu, X Hu, H Li, L Cao, Y Gao… - Human Brain …, 2021 - Wiley Online Library
Obsessive–compulsive disorder (OCD) displays alterations in regional brain activity
represented by the amplitude of low‐frequency fluctuation (ALFF), but the time‐varying …

Functional network connectivity in early-stage schizophrenia

TA Hummer, MG Yung, J Goñi, SK Conroy… - Schizophrenia …, 2020 - Elsevier
Schizophrenia is a disorder of altered neural connections resulting in impaired information
integration. Whole brain assessment of within-and between-network connections may …

Toward integrated understanding of salience in psychosis

J Miyata - Neurobiology of disease, 2019 - Elsevier
Attribution of abnormally heightened salience to daily-life stimuli is considered to underlie
psychosis. Dopaminergic hyperactivity in the midbrain-striatum is thought to cause such …

Temporal stability of the dynamic resting-state functional brain network: Current measures, clinical research progress, and future perspectives

Y Long, X Liu, Z Liu - Brain Sciences, 2023 - mdpi.com
Based on functional magnetic resonance imaging and multilayer dynamic network model,
the brain network's quantified temporal stability has shown potential in predicting altered …