Autophagy in DNA damage response

P Czarny, E Pawlowska… - International journal of …, 2015 - mdpi.com
DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but
autophagy is also suggested to play a role in DDR. Autophagy can be activated in response …

Autophagy: a potential therapeutic target of polyphenols in hepatocellular carcinoma

C Kiruthiga, KP Devi, SM Nabavi, A Bishayee - Cancers, 2020 - mdpi.com
Autophagy is a conserved biological phenomenon that maintains cellular homeostasis
through the clearing of damaged cellular components under cellular stress and offers the …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

[PDF][PDF] Guidelines for the use and interpretation of assays for monitoring autophagy

DJ Klionsky, K Abdelmohsen, MJ Abedin, A Abe - autophagy, 2016 - repository.upenn.edu
Many researchers, especially those new to the field, need to determine which criteria are
essential for demonstrating autophagy, either for the purposes of their own research, or in …

Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in …

W Yang, H Tang, Y Zhang, X Tang, J Zhang… - The American Journal of …, 2013 - cell.com
Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong
genetic involvement and ethnic differences. Susceptibility genes identified so far only …

[HTML][HTML] The human VRK1 chromatin kinase in cancer biology

I Campillo-Marcos, R García-González… - Cancer letters, 2021 - Elsevier
VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is
overexpressed in many types of tumors and associated with a poor prognosis. Chromatin …

[HTML][HTML] VRK1 variants at the cross road of Cajal body neuropathogenic mechanisms in distal neuropathies and motor neuron diseases

PA Lazo, P Morejón-García - Neurobiology of Disease, 2023 - Elsevier
Distal hereditary neuropathies and neuro motor diseases are complex neurological
phenotypes associated with pathogenic variants in a large number of genes, but in some the …

[HTML][HTML] Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer cells by activating VRK1/P53BP1 pathway

T Liu, L Zuo, D Guo, X Chai, J Xu, Z Cui, Z Wang… - Biomedicine & …, 2019 - Elsevier
Lung cancer is the leading cause of cancer-related deaths. Ginsenoside Rg3 is the main
ingredient of Ginseng which is used to treat non-small cell lung cancer (NSCLC). It has been …

DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells—Implications for age-related macular degeneration (AMD)

JMT Hyttinen, J Błasiak, M Niittykoski… - Ageing Research …, 2017 - Elsevier
In this review we will discuss the links between autophagy, a mechanism involved in the
maintenance of cellular homeostasis and controlling cellular waste management, and the …

Autophagy and immunological aberrations in systemic lupus erythematosus

Y Qi, X Zhou, H Zhang - European journal of immunology, 2019 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a complex autoimmune disease, in which immune
defects can occur at multiple points of the cascading auto‐aggressive immune reactions …