Abstract Evaluation of tissues is a common and important aspect of translational research
studies. Labeling techniques such as immunohistochemistry can stain cells/tissues to …

Neuroendocrine tumors (NETs) are originating from neuroendocrine cells in diffuse
endocrine systems. NETs are diagnosed by characteristic histologic features and …

Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …

Abstract Purpose: Pancreatic neuroendocrine tumors (PanNET) are a heterogeneous group
of neoplasms with increasing incidence and unpredictable behavior. Whole-exome …

Somatostatin receptor 2A expression is a feature of well-differentiated neuroendocrine
neoplasms and is important for their diagnosis and therapy. Little is known about …

In 1983, a monoclonal antibody, Ki67, was generated, that labeled the nuclei of proliferating
non-neoplastic and neoplastic cells. The name Ki67 derived from the city of Kiel (Ki) where …

Context.—Gastrointestinal (GI) and pancreatobiliary tracts contain a variety of
neuroendocrine cells that constitute a diffuse endocrine system. Neuroendocrine tumors …

Abstract In 2010, the World Health Organization (WHO) classification of neuroendocrine
neoplasms was reviewed and validated the crucial role of the proliferative rate. According to …

Neuroendocrine tumors of the lung (Lu-NETs) embrace a heterogeneous family of
neoplasms classified into four histological variants, namely typical carcinoid (TC), atypical …

Ki-67 assessment is a key step in the diagnosis of neuroendocrine neoplasms (NENs) from
all anatomic locations. Several challenges exist related to quantifying the Ki-67 proliferation …