Chondrocyte hypertrophy in osteoarthritis: mechanistic studies and models for the identification of new therapeutic strategies

S Chawla, A Mainardi, N Majumder, L Dönges… - Cells, 2022 - mdpi.com
Articular cartilage shows limited self-healing ability owing to its low cellularity and
avascularity. Untreated cartilage defects display an increased propensity to degenerate …

Conditioned medium–is it an undervalued lab waste with the potential for osteoarthritis management?

MA Rosochowicz, MS Lach, M Richter… - Stem Cell Reviews and …, 2023 - Springer
Background The approaches currently used in osteoarthritis (OA) are mainly short-term
solutions with unsatisfactory outcomes. Cell-based therapies are still controversial (in terms …

Nanosilicate‐reinforced silk fibroin hydrogel for endogenous regeneration of both cartilage and subchondral bone

R Sheng, J Chen, H Wang, Y Luo, J Liu… - Advanced …, 2022 - Wiley Online Library
Osteochondral defects are characterized by injuries to both cartilage and subchondral bone,
which is a result of trauma, inflammation, or inappropriate loading. Due to the unique …

Development of a microfluidic vascularized osteochondral model as a drug testing platform for osteoarthritis

S Salehi, S Brambilla, M Rasponi… - Advanced Healthcare …, 2024 - Wiley Online Library
Osteoarthritis (OA) is a degenerative joint disease characterized by changes in cartilage and
subchondral bone. To date, there are no available drugs that can counteract the progression …

Diversity of vascular niches in bones and joints during homeostasis, ageing, and diseases

N Kumar, P Saraber, Z Ding, AP Kusumbe - Frontiers in Immunology, 2021 - frontiersin.org
The bones and joints in the skeletal system are composed of diverse cell types, including
vascular niches, bone cells, connective tissue cells and mineral deposits and regulate whole …

A vascularized microfluidic model of the osteochondral unit for modeling inflammatory response and therapeutic screening

KD Roehm, I Chiesa, D Haithcock, R Gottardi… - Lab on a Chip, 2025 - pubs.rsc.org
Osteoarthritis (OA) has long been considered a disease of the articular cartilage. Within the
past decade it has become increasingly clear that OA is a disease of the entire joint space …

[HTML][HTML] Genetic influences of the effect of circulating inflammatory cytokines on osteoarthritis in humans

G Huang, W Li, H Kan, X Lu, W Liao, X Zhao - Osteoarthritis and Cartilage, 2023 - Elsevier
Objective The causal relationship between inflammatory cytokines and Osteoarthritis (OA)
has not been well investigated. This study investigated the causal role of inflammatory …

The added value of the “co” in co-culture systems in research on osteoarthritis pathology and treatment development

KA Muenzebrock, V Kersten, J Alblas… - … in bioengineering and …, 2022 - frontiersin.org
Osteoarthritis (OA) is a highly prevalent disease and a major health burden. Its development
and progression are influenced by factors such as age, obesity or joint overuse. As a whole …

Mechanisms of vascular invasion after cartilage injury and potential engineering cartilage treatment strategies

Z Zhao, X Sun, P Tu, Y Ma, Y Guo, Y Zhang… - The FASEB …, 2024 - Wiley Online Library
Articular cartilage injury is one of the most common diseases in orthopedic clinics. Following
an articular cartilage injury, an inability to resist vascular invasion can result in cartilage …

血管生成在骨关节炎中的作用机制及治疗启示

刘映鸿, 伊亚婷 - 中国组织工程研究, 2023 - cjter.com
血管生成在骨关节炎中的作用机制及治疗启示 Page 1 Chinese Journal of Tissue Engineering
Research|Vol 27|No.2|January 2023|307 中国组织工程研究 Chinese Journal of Tissue …