The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors
that participate in the modulation of synaptic transmission and neuronal excitability …

Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

G protein-coupled receptors (GPCRs) mediate physiological responses to various ligands,
such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking …

The plethora of functions of glutamate in the brain are mediated by the complementary
actions of ionotropic and metabotropic glutamate receptors (mGluRs). The ionotropic …

G protein-coupled receptors (GPCRs) are key transmembrane recognition molecules for
regulatory signals such as light, odors, taste hormones, and neurotransmitters. In addition to …

G protein–coupled receptors (GPCRs) contribute to the regulation of every aspect of human
physiology and are therapeutic targets for the treatment of numerous diseases. As a …

Psychiatric disorders such as schizophrenia are commonly accompanied by cognitive
impairments that are treatment resistant and crucial to functional outcome. There has been …

Hippocampal network activity is generated by a complex interplay between excitatory
pyramidal cells and inhibitory interneurons. Although much is known about the molecular …

GABAergic interneurons are highly heterogeneous, and much is unknown about the
specification and functional roles of their neural circuits. Here we show that a …

Introduction: Several drugs targeting the GABAergic system are used in the treatment of
epilepsy, but only one drug targeting glutamate receptors is on the market. This is surprising …