Heterocyclic compounds as a magic bullet for diabetes mellitus: a review
Diabetes mellitus (DM) is a major metabolic disorder due to hyperglycemia, which is
increasing all over the world. From the last two decades, the use of synthetic agents has …
increasing all over the world. From the last two decades, the use of synthetic agents has …
Pyrimidine derivatives as EGFR tyrosine kinase inhibitors in non‐small‐cell lung cancer: A comprehensive review
A Kizhakkedath Ratheesh… - Chemical Biology & …, 2022 - Wiley Online Library
EGFR‐positive non‐small‐cell lung cancer (NSCLC) due to primary mutation (EGFR DEL19
& L858R) has been recognized as a crucial mediator of tumor progression. This led to the …
& L858R) has been recognized as a crucial mediator of tumor progression. This led to the …
Design, synthesis, and antihypertensive activity of new pyrimidine derivatives endowing new pharmacophores
A new series of achiral pyrimidine derivatives based on nifedipine-like structure was
designed and synthesized. These pyrimidyl derivatives contained hydrazine, hydrazones …
designed and synthesized. These pyrimidyl derivatives contained hydrazine, hydrazones …
[PDF][PDF] Inhibition of α-amylase and α-glucosidase by (6rs)-22-hydroxy-23, 24, 25, 26, 27-pentanor-vitamin-d3-6, 19-sulfurdioxide-adduct, manoalide and 5β-cholestane …
Objective: This investigation includes characterization of phytochemicals from acetone
extract of Helianthus annuus L. seeds responsible for αamylase and α-glucosidase …
extract of Helianthus annuus L. seeds responsible for αamylase and α-glucosidase …
[PDF][PDF] Pyrimidine candidate as promising scaffold and their biological evaluation
Aromatic organic heterocycle containing pyrimidine scaffolds possesses two nitrogen atoms
of six-membered ring. These Pyrimidine skeletons comprise various ranges of …
of six-membered ring. These Pyrimidine skeletons comprise various ranges of …
[PDF][PDF] Structure-based drug designing, scoring, and synthesis of some substituted sulphonylureas/guanidine-based derivatives as hypoglycemic agents
Objective: The present work deals with the designing, scoring, synthesis and,
characterization of 1-(4-(2-(4-Substitutedphenylamino)-2-oxoethyl) phenylsulfonyl)-3-(4 …
characterization of 1-(4-(2-(4-Substitutedphenylamino)-2-oxoethyl) phenylsulfonyl)-3-(4 …
[PDF][PDF] Design, synthesis and biological evaluation of some substituted sulphonyl urea/guanidine derivatives as hypoglycemic agents
Diabetes mellitus is a major degenerative disease associated with a group of disorders of
carbohydrate metabolism results from the body's failure to produce insulin in type 1 and …
carbohydrate metabolism results from the body's failure to produce insulin in type 1 and …
[PDF][PDF] Molecular docking and synthesis of some substituted Sulphonylurea/Pyrrolidine-based derivatives as hypoglycemic agents
ABSTRACT A series of 1-(4-substitutedbenzoyl)-3-(4-(2-oxo-2-(pyrrolidin-1 yl) ethyl)
phenylsulfonyl) urea/gaunidine (5A-5F) and1-(4-(2-(4-methoxyphenylamino)-2-oxoethyl) …
phenylsulfonyl) urea/gaunidine (5A-5F) and1-(4-(2-(4-methoxyphenylamino)-2-oxoethyl) …
Design and synthesis of newly substituted 2-(2-Hydroxyethylamino) pyrimidine-5-carbonitrile with potential anticancer and antimicrobial activities
S Abdel-Aziz - Zagazig Journal of Pharmaceutical Sciences, 2016 - zjps.journals.ekb.eg
A series of 1, 6-dihydro-2-hydroxyethylamino-6-oxo-4-arylpyrimidine-5-carbonitriles 8a-i,
and 4-amino-2-hydroxyethylamino-6-arylpyrimidine-5-carbonitriles 9a-i were prepared …
and 4-amino-2-hydroxyethylamino-6-arylpyrimidine-5-carbonitriles 9a-i were prepared …