The STUB1 gene (STIP1 homology and U-box-containing protein 1), located at 16q13. 3,
encodes the CHIP (carboxyl terminus of Hsc70-interacting protein), an essential E3 ligase …

Cardiovascular diseases cause more mortality and morbidity worldwide than any other
diseases. Although many intracellular signaling pathways influence cardiac physiology and …

Lung injury, whether induced by infection or caustic chemicals, initiates a series of complex
wound-healing responses. If uncontrolled, these responses may lead to fibrotic lung …

Recurrence and drug resistance of breast cancer are still the main reasons for breast cancer-
associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis for …

Deciphering the inositol-requiring enzyme 1 (IRE1) signaling pathway is fundamentally
important for understanding the unfolded protein response (UPR). The ubiquitination of …

ERK5, the last MAP kinase family member discovered, is activated by the upstream kinase
MEK5 in response to growth factors and stress stimulation. MEK5-ERK5 pathway has been …

Cells regularly synthesize new proteins to replace old and abnormal proteins for normal
cellular functions. Two significant protein quality control pathways inside the cellular milieu …

The carboxy‐terminus of Hsc70 interacting protein (CHIP) is a cochaperone E3 ligase
containing three tandem repeats of tetratricopeptide (TPR) motifs and a C‐terminal U‐box …

Rigorous surveillance of protein quality control is essential for the maintenance of normal
cardiac function, while the dysregulation of protein turnover is present in a diverse array of …

Aims High mobility group box 1 (HMGB1) is an abundant and ubiquitous nuclear DNA-
binding protein that has multiple functions dependent on its cellular location. HMGB1 binds …