Nociceptin/orphanin FQ receptor structure, signaling, ligands, functions, and interactions with opioid systems
L Toll, MR Bruchas, BM Cox, NT Zaveri… - Pharmacological …, 2016 - Elsevier
The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …
discovered member of the opioid receptor family and, together with its endogenous ligand …
Review on CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
TM Tzschentke - Addiction biology, 2007 - Wiley Online Library
Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …
study the motivational effects of drugs and non‐drug treatments in experimental animals …
Endogenous opioid systems alterations in pain and opioid use disorder
JA Higginbotham, T Markovic, N Massaly… - Frontiers in systems …, 2022 - frontiersin.org
Decades of research advances have established a central role for endogenous opioid
systems in regulating reward processing, mood, motivation, learning and memory …
systems in regulating reward processing, mood, motivation, learning and memory …
The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential
DG Lambert - Nature reviews Drug discovery, 2008 - nature.com
Identification of the enigmatic nociceptin/orphanin FQ peptide (N/OFQ) in 1995 represented
the first successful use of reverse pharmacology and led to deorphanization of the N/OFQ …
the first successful use of reverse pharmacology and led to deorphanization of the N/OFQ …
The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence
JM Witkin, MA Statnick, LM Rorick-Kehn… - Pharmacology & …, 2014 - Elsevier
Abstract Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized
in 1995. The generation of specific agonists, antagonists and receptor deficient mice and …
in 1995. The generation of specific agonists, antagonists and receptor deficient mice and …
A paranigral VTA nociceptin circuit that constrains motivation for reward
Nociceptin and its receptor are widely distributed throughout the brain in regions associated
with reward behavior, yet how and when they act is unknown. Here, we dissected the role of …
with reward behavior, yet how and when they act is unknown. Here, we dissected the role of …
Nociceptin opioid receptor (NOP) as a therapeutic target: progress in translation from preclinical research to clinical utility: miniperspective
NT Zaveri - Journal of medicinal chemistry, 2016 - ACS Publications
In the two decades since the discovery of the nociceptin opioid receptor (NOP) and its
ligand, nociceptin/orphaninFQ (N/OFQ), steady progress has been achieved in …
ligand, nociceptin/orphaninFQ (N/OFQ), steady progress has been achieved in …
Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol …
R Ciccocioppo, D Economidou, A Fedeli… - …, 2004 - Springer
Abstract Rationale Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the opioid-
like orphan receptor NOP, was shown to reduce home-cage ethanol consumption, ethanol …
like orphan receptor NOP, was shown to reduce home-cage ethanol consumption, ethanol …
Molecular imaging of opioid and dopamine systems: insights into the pharmacogenetics of opioid use disorders
JA Burns, DS Kroll, DE Feldman, C Kure Liu… - Frontiers in …, 2019 - frontiersin.org
Opioid use in the United States has steadily risen since the 1990s, along with staggering
increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid …
increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid …