Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …

The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The recently discovered epithelial sodium channel (ENaC)/degenerin (DEG) gene family
encodes sodium channels involved in various cell functions in metazoans. Subfamilies …

Extracellular ATP is implicated in numerous sensory processes ranging from the response to
pain to the regulation of motility in visceral organs. The ATP receptor P2X3 is selectively …

Many central neurons possess large acid-activated currents, yet their molecular identity is
unknown. We found that eliminating the acid sensing ion channel (ASIC) abolished H+ …

Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

Cation channels in the DEG/ENaC family are proposed to detect cutaneous stimuli in
mammals. We localized one such channel, DRASIC, in several different specialized sensory …

The acid-sensing ion channel, ASIC1, contributes to synaptic plasticity in the hippocampus
and to hippocampus-dependent spatial memory. To explore the role of ASIC1 in brain, we …