Central role of microglia in sepsis-associated encephalopathy: from mechanism to therapy

X Yan, K Yang, Q Xiao, R Hou, X Pan… - Frontiers in …, 2022 - frontiersin.org
Sepsis-associated encephalopathy (SAE) is a cognitive impairment associated with sepsis
that occurs in the absence of direct infection in the central nervous system or structural brain …

Neuronal loss after stroke due to microglial phagocytosis of stressed neurons

GC Brown - International journal of molecular sciences, 2021 - mdpi.com
After stroke, there is a rapid necrosis of all cells in the infarct, followed by a delayed loss of
neurons both in brain areas surrounding the infarct, known as 'selective neuronal loss', and …

Shared metabolic shifts in endothelial cells in stroke and Alzheimer's disease revealed by integrated analysis

G Guo, L Fan, Y Yan, Y Xu, Z Deng, M Tian, Y Geng… - Scientific Data, 2023 - nature.com
Since metabolic dysregulation is a hallmark of both stroke and Alzheimer's disease (AD),
mining shared metabolic patterns in these diseases will help to identify their possible …

Astrocytosis, inflammation, axonal damage and myelin impairment in the internal capsule following striatal ischemic injury

MAM Freire, RR Lima, LO Bittencourt, JS Guimaraes… - Cells, 2023 - mdpi.com
Secondary degeneration is defined as a set of destructive events that damage cells and
structures that were initially spared or only peripherally affected by the primary insult …

Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage

P Zeng, XM Wang, HF Su, T Zhang, LN Ning, Y Shi… - Phytomedicine, 2021 - Elsevier
Background Intracerebral hemorrhage (ICH), the most fatal subtype of stroke, has no
disease-modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of …

Distinct alterations of retinal structure between thalamic and extra‐thalamic subcortical infarction patients: A cross‐sectional and longitudinal study

R Pan, C Ye, Z Zhang, WR Kwapong… - CNS Neuroscience …, 2024 - Wiley Online Library
Aims Cerebrovascular lesions in the primary visual cortex, the lateral geniculate nucleus,
and the optic tract have been associated with retinal neurodegeneration via the retrograde …

Long-term structural brain changes in adult rats after mild ischaemic stroke

W Syeda, CM Ermine, MS Khilf, D Wright… - Brain …, 2022 - academic.oup.com
Preclinical studies of remote degeneration have largely focused on brain changes over the
first few days or weeks after stroke. Accumulating evidence suggests that …

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

Y Wang, Y Li, Y Gu, W Ma, Y Guan, M Guo… - Neural Regeneration …, 2025 - journals.lww.com
Poststroke cognitive impairment is a major secondary effect of ischemic stroke in many
patients; however, few options are available for the early diagnosis and treatment of this …

M1 型小胶质细胞极化在大脑皮层梗死后继发丘脑损伤中的作用.

石喆, 左夏林, 彭林辉, 卢志伟… - Journal of Practical …, 2024 - search.ebscohost.com
目的探讨M1 型小胶质细胞极化在大脑皮层梗死后继发丘脑损伤中的作用. 方法使用电凝法制备
成年雄性SD 大鼠的局灶性皮层梗死模型, 并将其随机分为假手术组和术后1~ 4 …

Urinary AD7c-NTP is Associated With Cognitive Recovery After Ischemic Stroke

Y Wang, H Tao, M Cao, K Cai - Alzheimer Disease & Associated …, 2024 - journals.lww.com
Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is regarded as a
biomarker for β-amyloid protein deposition in Alzheimer disease (AD). The value of AD7c …