Conformational plasticity of DNA secondary structures: Probing the conversion between i-motif and hairpin species by circular dichroism and ultraviolet resonance …
J Amato, N Iaccarino, F D'Aria, F D'Amico… - Physical Chemistry …, 2022 - pubs.rsc.org
The promoter regions of important oncogenes such as BCL2 and KRAS contain GC-rich
sequences that can form distinctive noncanonical DNA structures involved in the regulation …
sequences that can form distinctive noncanonical DNA structures involved in the regulation …
Ligand binding to G-quadruplex DNA: New insights from ultraviolet resonance Raman spectroscopy
S Di Fonzo, J Amato, F D'Aria, M Caterino… - Physical Chemistry …, 2020 - pubs.rsc.org
G-Quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of
several biological processes of many organisms. The rational design of G4-targeting …
several biological processes of many organisms. The rational design of G4-targeting …
DNA-based optical quantification of ion transport across giant vesicles
Accurate measurements of ion permeability through cellular membranes remains
challenging due to the lack of suitable ion-selective probes. Here we use giant unilamellar …
challenging due to the lack of suitable ion-selective probes. Here we use giant unilamellar …
BMPQ-1 binds selectively to (3+ 1) hybrid topologies in human telomeric G-quadruplex multimers
C Gao, Z Liu, H Hou, J Ding, X Chen, C Xie… - Nucleic acids …, 2020 - academic.oup.com
A single G-quadruplex forming sequence from the human telomere can adopt six distinct
topologies that are inter-convertible under physiological conditions. This presents …
topologies that are inter-convertible under physiological conditions. This presents …
[HTML][HTML] Molecular mechanisms behind BRACO19 and human telomeric G-quadruplex interaction
Human telomeres (HTs) can form DNA G-quadruplex (G4), an attractive target for anticancer
and antiviral drugs. HT-G4s exhibit inherent structural polymorphism, posing challenges for …
and antiviral drugs. HT-G4s exhibit inherent structural polymorphism, posing challenges for …
Exploring the parallel G-quadruplex nucleic acid world: a spectroscopic and computational investigation on the binding of the c-myc oncogene nhe III1 region by the …
F Greco, D Musumeci, N Borbone, AP Falanga… - Molecules, 2022 - mdpi.com
Trans-polydatin (tPD), the 3-β-D-glucoside of the well-known nutraceutical trans-resveratrol,
is a natural polyphenol with documented anti-cancer, anti-inflammatory, cardioprotective …
is a natural polyphenol with documented anti-cancer, anti-inflammatory, cardioprotective …
Unlocking the power of resonance Raman spectroscopy: The case of amides in aqueous solution
We report a joined experimental and computational study of Raman and Resonance Raman
spectra of amides in aqueous solution. By employing state-of-the-art QM/MM methods …
spectra of amides in aqueous solution. By employing state-of-the-art QM/MM methods …
Local and cooperative structural transitions of double-stranded DNA in choline-based deep eutectic solvents
The possibility of using deep eutectic solvents (DESs) as co-solvents for stabilizing and
preserving the native structure of DNA provides an attractive opportunity in the field of DNA …
preserving the native structure of DNA provides an attractive opportunity in the field of DNA …
Porphyrin binding and irradiation promote G-quadruplex DNA dimeric structure
Nucleic acid sequences rich in guanines can organize into noncanonical DNA G-
quadruplexes (G4s) of variable size. The design of small molecules stabilizing the structure …
quadruplexes (G4s) of variable size. The design of small molecules stabilizing the structure …
Polymorphism and ligand binding modulate fast dynamics of human telomeric G-quadruplexes
Telomeric G-quadruplexes (G4s) are promising targets in the design and development of
anticancer drugs. Their actual topology depends on several factors, resulting in structural …
anticancer drugs. Their actual topology depends on several factors, resulting in structural …