Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections

LM Ney, M Wipplinger, M Grossmann… - Open …, 2023 - royalsocietypublishing.org
The human intestinal microbiome substantially affects human health and resistance to
infections in its dynamic composition and varying release of microbial-derived metabolites …

[HTML][HTML] Short chain fatty acids, a possible treatment option for autoimmune diseases

F Golpour, M Abbasi-Alaei, F Babaei… - Biomedicine & …, 2023 - Elsevier
Gut microbiota can interact with the immune system through its metabolites. Short-chain fatty
acids (SCFAs), as one of the most abundant metabolites of the resident gut microbiota play …

[HTML][HTML] Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma

Q Song, X Zhang, W Liu, H Wei, W Liang, Y Zhou… - Journal of …, 2023 - Elsevier
Background & Aims Recent studies have highlighted the role of the gut microbiota and their
metabolites in non-alcoholic fatty liver disease-associated hepatocellular carcinoma …

Interplay between gut microbiome, host genetic and epigenetic modifications in MASLD and MASLD-related hepatocellular carcinoma

S Ha, VWS Wong, X Zhang, J Yu - Gut, 2025 - gut.bmj.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a wide
spectrum of liver injuries, ranging from hepatic steatosis, metabolic dysfunction-associated …

Immunomodulatory effects of inulin and its intestinal metabolites

W Sheng, G Ji, L Zhang - Frontiers in Immunology, 2023 - frontiersin.org
“Dietary fiber”(DF) refers to a type of carbohydrate that cannot be digested fully. DF is not an
essential nutrient, but it plays an important part in enhancing digestive capacity and …

Gut microbiota-derived short-chain fatty acids regulate gastrointestinal tumor immunity: a novel therapeutic strategy?

Y Dong, K Zhang, J Wei, Y Ding, X Wang… - Frontiers in …, 2023 - frontiersin.org
Tumor immune microenvironment (TIME), a tumor-derived immune component, is proven to
be closely related to the development, metastasis, and recurrence of tumors. Gut microbiota …

The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities

K Mima, T Hamada, K Inamura, H Baba, T Ugai… - Gut …, 2023 - Taylor & Francis
Accumulating evidence indicates an alarming increase in the incidence of early-onset
cancers, which are diagnosed among adults under 50 years of age, in the colorectum …

Gut microbiota modulate CD8+ T cell immunity in gastric cancer through Butyrate/GPR109A/HOPX

X Yu, J Ou, L Wang, Z Li, Y Ren, L Xie, Z Chen… - Gut …, 2024 - Taylor & Francis
The gut microbiota and Short-chain fatty acids (SCFAs) can influence the progression of
diseases, yet the role of these factors on gastric cancer (GC) remains uncertain. In this work …

[HTML][HTML] The role of gut microbiome-derived short chain fatty acid butyrate in hepatobiliary diseases

K Pant, SK Venugopal, MJL Pisarello… - The American Journal of …, 2023 - Elsevier
The multiple beneficial effects of the short-chain fatty acid (SCFA) butyrate on human health,
produced from fermentable carbohydrates by gut microbiota in the colon, are well known. At …

[HTML][HTML] Role of gut microbial metabolites in the pathogenesis of primary liver cancers

M Pallozzi, V De Gaetano, N Di Tommaso, L Cerrito… - Nutrients, 2024 - mdpi.com
Hepatobiliary malignancies, which include hepatocellular carcinoma (HCC) and
cholangiocarcinoma (CCA), are the sixth most common cancers and the third leading cause …