Being one of the main proteins in the human body and many animal species, albumin plays
a decisive role in the transport of various ions—electrically neutral and charged molecules …

Accumulation of advanced glycation end products (AGEs) on nucleotides, lipids, and
peptides/proteins are an inevitable component of the aging process in all eukaryotic …

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …

Type 2 diabetes mellitus (T2DM) is a very complex and multifactorial metabolic disease
characterized by insulin resistance and β cell failure leading to elevated blood glucose …

Renal fibrosis is the histological manifestation of a progressive, usually irreversible process
causing chronic and end-stage kidney disease. We performed genome-wide transcriptome …

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

Diabetic kidney disease (DKD), as the most common complication of diabetes mellitus (DM),
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …

During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent
adducts with the plasma proteins through a non-enzymatic process known as glycation …

Diabetic Nephropathy (DN) is a serious complication of type I and II diabetes. It develops
from the initial microproteinuria to end-stage renal failure. The main initiator for DN is chronic …

Both type 1 and type 2 diabetes are associated with cardiac fibrosis that may reduce
myocardial compliance, contribute to the pathogenesis of heart failure, and trigger …