The wingless/int1 (WNT)/F rizzled (FZD) signalling pathway controls numerous cellular
processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a …

Frizzled proteins are the principal receptors for the Wnt family of ligands. They mediate
canonical Wnt signaling together with Lrp5 and Lrp6 coreceptors. In conjunction with Celsr …

The seven-transmembrane-spanning receptors of the FZD 1–10 class are bound and
activated by the WNT family of lipoglycoproteins, thereby inducing a complex network of …

The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and
functional diversity and mediates a myriad of biological processes upon activation by …

Liver tumor-initiating cells (TICs), the drivers for liver tumorigenesis, accounts for liver tumor
initiation, metastasis, drug resistance and relapse. Wnt/β-catenin signaling pathway …

Importance Nail dystrophy in early childhood often suggests a diagnosis of pachyonychia
congenita (PC). No previous investigation has focused on the early signs of PC and the …

Oral squamous cell carcinoma (OSCC) accounts for approximately 90% of malignant
epithelial tumors of the oral and maxillofacial region. OSCC has high rate of metastasis and …

Hypoxia–ischaemia (HI) remains a major cause of foetal brain damage presented a scarcity
of effective therapeutic approaches. Dexmedetomidine (DEX) and micro RNA‐140‐5p (miR …

The WNT receptors of the Frizzled family comprise ten mammalian isoforms, bind WNT
proteins and mediate downstream signaling to regulate stem cell fate, neuronal …

Cells expressing LGR5 play a pivotal role in homeostasis, repair, and regeneration in
multiple organs including skin and gastrointestinal tract, yet little is known about their role in …