Disruptions in iron homeostasis from both iron deficiency and overload account for some of
the most common human diseases. Iron metabolism is balanced by two regulatory systems …

Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Reactive Oxygen Species (ROS) are produced during normal cellular function. ROS include
hydroxyl radicals, superoxide anion, hydrogen peroxide and nitric oxide. They are very …

Iron is ubiquitous in the environment and in biology. The study of iron biology focuses on
physiology and homeostasis—understanding how cells and organisms regulate their iron …

Increasingly, perturbations in cellular iron and ferritin are emerging as an important element
in the pathogenesis of disease. These changes in ferritin are important not only in the classic …

Iron is an essential nutrient with limited bioavailability. When present in excess, iron poses a
threat to cells and tissues, and therefore iron homeostasis has to be tightly controlled. Iron's …

The membrane transferrin receptor-mediated endocytosis or internalization of the complex
of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake …

Reactive oxygen species are produced by all aerobic cells and are widely believed to play a
pivotal role in aging as well as a number of degenerative diseases. The consequences of …

Neutrophil gelatinase–associated lipocalin (Ngal), also known as siderocalin, forms a
complex with iron-binding siderophores (Ngal: siderophore: Fe). This complex converts …