Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
Therapeutic implications of tumor microenvironment in lung cancer: focus on immune checkpoint blockade
C Genova, C Dellepiane, P Carrega… - Frontiers in …, 2022 - frontiersin.org
In the last decade, the treatment of non-small cell lung cancer (NSCLC) has been
revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against …
revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against …
GEPIA2021: integrating multiple deconvolution-based analysis into GEPIA
C Li, Z Tang, W Zhang, Z Ye, F Liu - Nucleic Acids Research, 2021 - academic.oup.com
In 2017, we released GEPIA (Gene Expression Profiling Interactive Analysis) webserver to
facilitate the widely used analyses based on the bulk gene expression datasets in the TCGA …
facilitate the widely used analyses based on the bulk gene expression datasets in the TCGA …
TIMER2. 0 for analysis of tumor-infiltrating immune cells
Tumor progression and the efficacy of immunotherapy are strongly influenced by the
composition and abundance of immune cells in the tumor microenvironment. Due to the …
composition and abundance of immune cells in the tumor microenvironment. Due to the …
Benchmarking of cell type deconvolution pipelines for transcriptomics data
F Avila Cobos, J Alquicira-Hernandez… - Nature …, 2020 - nature.com
Many computational methods have been developed to infer cell type proportions from bulk
transcriptomics data. However, an evaluation of the impact of data transformation, pre …
transcriptomics data. However, an evaluation of the impact of data transformation, pre …
IOBR: multi-omics immuno-oncology biological research to decode tumor microenvironment and signatures
Recent advances in next-generation sequencing (NGS) technologies have triggered the
rapid accumulation of publicly available multi-omics datasets. The application of integrated …
rapid accumulation of publicly available multi-omics datasets. The application of integrated …
Hiplot: a comprehensive and easy-to-use web service for boosting publication-ready biomedical data visualization
Complex biomedical data generated during clinical, omics and mechanism-based
experiments have increasingly been exploited through cloud-and visualization-based data …
experiments have increasingly been exploited through cloud-and visualization-based data …
[HTML][HTML] Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer
Rationale: Siglec15 is an emerging target for normalization cancer immunotherapy.
However, pan-cancer anti-Siglec15 treatment is not yet validated and the potential role of …
However, pan-cancer anti-Siglec15 treatment is not yet validated and the potential role of …
Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology
Motivation The composition and density of immune cells in the tumor microenvironment
(TME) profoundly influence tumor progression and success of anti-cancer therapies. Flow …
(TME) profoundly influence tumor progression and success of anti-cancer therapies. Flow …
Crosstalk between 5-methylcytosine and N6-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in …
Y Tian, H Xiao, Y Yang, P Zhang, J Yuan, W Zhang… - Molecular cancer, 2023 - Springer
Background Accumulated evidence highlights the significance of the crosstalk between
epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) and N6 …
epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) and N6 …