Spatial landscapes of cancers: insights and opportunities
J Chen, L Larsson, A Swarbrick… - Nature Reviews Clinical …, 2024 - nature.com
Solid tumours comprise many different cell types organized in spatially structured
arrangements, with substantial intratumour and intertumour heterogeneity. Advances in …
arrangements, with substantial intratumour and intertumour heterogeneity. Advances in …
[HTML][HTML] CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
B Kruse, AC Buzzai, N Shridhar, AD Braun, S Gellert… - Nature, 2023 - nature.com
Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to
directly recognize and kill tumour cells,–. These strategies are limited by the emergence of …
directly recognize and kill tumour cells,–. These strategies are limited by the emergence of …
The current landscape of spatial biomarkers for prediction of response to immune checkpoint inhibition
Enabling the examination of cell-cell relationships in tissue, spatially resolved omics
technologies have revolutionised our perspectives on cancer biology. Clinically, the …
technologies have revolutionised our perspectives on cancer biology. Clinically, the …
Deep learning-based scoring of tumour-infiltrating lymphocytes is prognostic in primary melanoma and predictive to PD-1 checkpoint inhibition in melanoma …
Background Recent advances in digital pathology have enabled accurate and standardised
enumeration of tumour-infiltrating lymphocytes (TILs). Here, we aim to evaluate TILs as a …
enumeration of tumour-infiltrating lymphocytes (TILs). Here, we aim to evaluate TILs as a …
The interface of tumour-associated macrophages with dying cancer cells in immuno-oncology
Tumour-associated macrophages (TAMs) are essential players in the tumour
microenvironment (TME) and modulate various pro-tumorigenic functions such as …
microenvironment (TME) and modulate various pro-tumorigenic functions such as …
Tumor battlefield within inflamed, excluded or desert immune phenotypes: the mechanisms and strategies
S Zheng, W Wang, L Shen, Y Yao, W Xia… - … Hematology & Oncology, 2024 - Springer
The tumor microenvironment demonstrates great immunophenotypic heterogeneity, which
has been leveraged in traditional immune-hot/cold tumor categorization based on the …
has been leveraged in traditional immune-hot/cold tumor categorization based on the …
Macrophage barrier in the tumor microenvironment and potential clinical applications
S Ji, Y Shi, B Yin - Cell Communication and Signaling, 2024 - Springer
The tumor microenvironment (TME) constitutes a complex microenvironment comprising a
diverse array of immune cells and stromal components. Within this intricate context, tumor …
diverse array of immune cells and stromal components. Within this intricate context, tumor …
A spatial architecture-embedding HLA signature to predict clinical response to immunotherapy in renal cell carcinoma
An important challenge in the real-world management of patients with advanced clear-cell
renal cell carcinoma (aRCC) is determining who might benefit from immune checkpoint …
renal cell carcinoma (aRCC) is determining who might benefit from immune checkpoint …
Genomic and Epigenomic Biomarkers of Immune Checkpoint Immunotherapy Response in Melanoma: Current and Future Perspectives
SM Hossain, C Carpenter, MR Eccles - International journal of molecular …, 2024 - mdpi.com
Immune checkpoint inhibitors (ICIs) demonstrate durable responses, long-term survival
benefits, and improved outcomes in cancer patients compared to chemotherapy. However …
benefits, and improved outcomes in cancer patients compared to chemotherapy. However …
Delineating spatial cell-cell interactions in the solid tumour microenvironment through the lens of highly multiplexed imaging
The growth and metastasis of solid tumours is known to be facilitated by the tumour
microenvironment (TME), which is composed of a highly diverse collection of cell types that …
microenvironment (TME), which is composed of a highly diverse collection of cell types that …