[HTML][HTML] Blebs—formation, regulation, positioning, and role in amoeboid cell migration

J Schick, E Raz - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
In the context of development, tissue homeostasis, immune surveillance, and pathological
conditions such as cancer metastasis and inflammation, migrating amoeboid cells …

Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins

A Arora, JH Taskinen, VM Olkkonen - Progress in lipid research, 2022 - Elsevier
Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute one of the
largest families of lipid-binding/transfer proteins (LTPs) in eukaryotes. The current view is …

Control of Gαq signaling dynamics and GPCR cross-talk by GRKs

G Xiang, A Acosta-Ruiz, A Radoux-Mergault… - Science …, 2022 - science.org
Numerous processes contribute to the regulation of G protein–coupled receptors (GPCRs),
but relatively little is known about rapid mechanisms that control signaling on the seconds …

[HTML][HTML] G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment

M Yang, CY Zhang - World Journal of Gastroenterology, 2021 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a broad-spectrum disease, ranging from simple
hepatic steatosis to nonalcoholic steatohepatitis, which can progress to cirrhosis and liver …

[HTML][HTML] TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors

S Curcic, H Erkan-Candag, J Pilic, R Malli, P Wiedner… - Cell Calcium, 2022 - Elsevier
Communication between TRPC channels and IP 3 receptors (IP 3 R) is considered pivotal in
the generation of spatiotemporal Ca 2+ signaling patterns. Here we revisited the role of …

[HTML][HTML] Calcium channels: noteworthy regulators and therapeutic targets in dermatological diseases

M Wang, Y Sun, L Li, P Wu, O Dkw, H Shi - Frontiers in pharmacology, 2021 - frontiersin.org
Dysfunctional skin barrier and impaired skin homeostasis may lead to or aggravate a series
of dermatologic diseases. A large variety of biological events and bioactive molecules are …

The emerging roles of OSBP-related proteins in cancer: Impacts through phosphoinositide metabolism and protein–protein interactions

VM Olkkonen - Biochemical pharmacology, 2022 - Elsevier
Oxysterol-binding protein-related proteins (ORPs) form a large family of intracellular lipid
binding/transfer proteins. A number of ORPs are implicated in inter-organelle lipid transfer …

[HTML][HTML] Cell fusion and syncytium formation in betaherpesvirus infection

J Tang, G Frascaroli, X Zhou, J Knickmann, W Brune - Viruses, 2021 - mdpi.com
Cell–cell fusion is a fundamental and complex process that occurs during reproduction,
organ and tissue growth, cancer metastasis, immune response, and infection. All enveloped …

Eye‐Mimicked Neural Network Composed of Photosensitive Neural Spheroids with Human Opsin Proteins

B Park, S Bang, KS Hwang, YK Cha, J Kwak… - Advanced …, 2023 - Wiley Online Library
An in vitro model, composed of the short‐wavelength human opsins and rhodopsins, is
created. Two types of photosensitive neural spheroids are transfected for selective reaction …

[HTML][HTML] Characterization of two distinct immortalized endothelial cell lines, EA. hy926 and HMEC-1, for in vitro studies: exploring the impact of calcium electroporation …

B Lisec, T Bozic, I Santek, B Markelc, M Vrecl… - Cell Communication and …, 2024 - Springer
Abstract Background Disruption of Ca2+ homeostasis after calcium electroporation (CaEP)
in tumors has been shown to elicit an enhanced antitumor effect with varying impacts on …