End-point binding free energy calculation with MM/PBSA and MM/GBSA: strategies and applications in drug design
Molecular mechanics Poisson–Boltzmann surface area (MM/PBSA) and molecular
mechanics generalized Born surface area (MM/GBSA) are arguably very popular methods …
mechanics generalized Born surface area (MM/GBSA) are arguably very popular methods …
The international society of RNA nanotechnology and nanomedicine (ISRNN): the present and future of the burgeoning field
M Chandler, B Johnson, E Khisamutdinov… - ACS …, 2021 - ACS Publications
The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) hosts an
annual meeting series focused on presenting the latest research achievements involving …
annual meeting series focused on presenting the latest research achievements involving …
[HTML][HTML] Characterization of epitranscriptome reader proteins experimentally and in silico: current knowledge and future perspectives beyond the YTH domain
To date, over 150 chemical modifications to the four canonical RNA bases have been
discovered, known collectively as the epitranscriptome. Many of these modifications have …
discovered, known collectively as the epitranscriptome. Many of these modifications have …
[HTML][HTML] Computational evolution of an RNA-binding protein towards enhanced oxidized-RNA binding
The oxidation of RNA has been implicated in the development of many diseases. Among the
four ribonucleotides, guanosine is the most susceptible to oxidation, resulting in the …
four ribonucleotides, guanosine is the most susceptible to oxidation, resulting in the …
Activation of COUP-TFI by a novel diindolylmethane derivative
Chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is an orphan
receptor and member of the nuclear receptor superfamily. Among a series of methylene …
receptor and member of the nuclear receptor superfamily. Among a series of methylene …
7, 8‐Dihydro‐8‐oxoguanosine Lesions Inhibit the Theophylline Aptamer or Change Its Selectivity
C Kiggins, A Skinner, MJE Resendiz - ChemBioChem, 2020 - Wiley Online Library
Aptamers are attractive constructs due to their high affinity/selectivity towards a target. Here
7, 8‐dihydro‐8‐oxoguanosine (8‐oxoG) has been used, due in part to its unique H‐bonding …
7, 8‐dihydro‐8‐oxoguanosine (8‐oxoG) has been used, due in part to its unique H‐bonding …
[PDF][PDF] RNA oxidation: role of polynucleotide phosphorylase in the quality control of oxidized RNA
S Malla, A Kwakye - RNA, 2021 - journaloflifesciences.org
Reactive oxygen species is one of the most common cellular RNA damaging agents in living
organisms. A growing number of studies show a strong correlation between oxidatively …
organisms. A growing number of studies show a strong correlation between oxidatively …
Experimental and computational methods for guiding identification and characterization of epitranscriptome proteins
Modifications to the four canonical RNA nucleotides decorate cellular RNAs, forming what is
collectively known as the epitranscriptome. A few of the well-studied RNA modifications (eg …
collectively known as the epitranscriptome. A few of the well-studied RNA modifications (eg …
Insights into the functional implications of environmental exposure in RNA modifications
JC Gonzalez Rivera - 2020 - repositories.lib.utexas.edu
RNA post-transcriptional modifications are changes to the chemical composition of
nucleotides that can reprogram RNA fate and functions. They have critical roles in cellular …
nucleotides that can reprogram RNA fate and functions. They have critical roles in cellular …