Metabolic remodelling in heart failure

E Bertero, C Maack - Nature Reviews Cardiology, 2018 - nature.com
The heart consumes large amounts of energy in the form of ATP that is continuously
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …

Nutrient regulation of signaling and transcription

GW Hart - Journal of Biological Chemistry, 2019 - ASBMB
In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …

Glucose metabolism in cardiac hypertrophy and heart failure

DH Tran, ZV Wang - Journal of the American Heart Association, 2019 - Am Heart Assoc
Heart failure is one of the leading causes of death worldwide and has been singled out as
an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …

Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology

JC Chatham, J Zhang, AR Wende - Physiological reviews, 2021 - journals.physiology.org
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Cardiac metabolism in heart failure: implications beyond ATP production

T Doenst, TD Nguyen, ED Abel - Circulation research, 2013 - Am Heart Assoc
The heart has a high rate of ATP production and turnover that is required to maintain its
continuous mechanical work. Perturbations in ATP-generating processes may therefore …

Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways

K Huynh, BC Bernardo, JR McMullen… - Pharmacology & …, 2014 - Elsevier
Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic
population. Both experimental and clinical evidence suggest that diabetic subjects are …

[HTML][HTML] Glucose transporters in cardiac metabolism and hypertrophy

D Shao, R Tian - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and
it tightly regulates its substrate utilization in response to environmental changes. Although …

AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

R Gélinas, F Mailleux, J Dontaine, L Bultot… - Nature …, 2018 - nature.com
AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here,
we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without …

Metabolomic analysis of pressure-overloaded and infarcted mouse hearts

BE Sansbury, AM DeMartino, Z Xie… - Circulation: heart …, 2014 - Am Heart Assoc
Background—Cardiac hypertrophy and heart failure are associated with metabolic
dysregulation and a state of chronic energy deficiency. Although several disparate changes …

Roles of O-GlcNAc in chronic diseases of aging

PS Banerjee, O Lagerlöf, GW Hart - Molecular aspects of medicine, 2016 - Elsevier
O-GlcNAcylation, a dynamic nutrient and stress sensitive post-translational modification,
occurs on myriad proteins in the cell nucleus, cytoplasm and mitochondria. O-GlcNAcylation …