GW Hart - Journal of Biological Chemistry, 2019 - ASBMB
In the early 1980s, while using purified glycosyltransferases to probe glycan structures on surfaces of living cells in the murine immune system, we discovered a novel form of …
DH Tran, ZV Wang - Journal of the American Heart Association, 2019 - Am Heart Assoc
Heart failure is one of the leading causes of death worldwide and has been singled out as an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …
In the mid-1980s, the identification of serine and threonine residues on nuclear and cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
The heart has a high rate of ATP production and turnover that is required to maintain its continuous mechanical work. Perturbations in ATP-generating processes may therefore …
Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic population. Both experimental and clinical evidence suggest that diabetic subjects are …
D Shao, R Tian - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
The heart is adapted to utilize all classes of substrates to meet the high-energy demand, and it tightly regulates its substrate utilization in response to environmental changes. Although …
R Gélinas, F Mailleux, J Dontaine, L Bultot… - Nature …, 2018 - nature.com
AMP-activated protein kinase (AMPK) has been shown to inhibit cardiac hypertrophy. Here, we show that submaximal AMPK activation blocks cardiomyocyte hypertrophy without …
BE Sansbury, AM DeMartino, Z Xie… - Circulation: heart …, 2014 - Am Heart Assoc
Background—Cardiac hypertrophy and heart failure are associated with metabolic dysregulation and a state of chronic energy deficiency. Although several disparate changes …
PS Banerjee, O Lagerlöf, GW Hart - Molecular aspects of medicine, 2016 - Elsevier
O-GlcNAcylation, a dynamic nutrient and stress sensitive post-translational modification, occurs on myriad proteins in the cell nucleus, cytoplasm and mitochondria. O-GlcNAcylation …