Small molecule selenium-containing compounds: Recent development and therapeutic applications

H Chuai, SQ Zhang, H Bai, J Li, Y Wang, J Sun… - European Journal of …, 2021 - Elsevier
Selenium (Se) is an essential micronutrient of organism and has important function. It
participates in the functions of selenoprotein in several manners. In recent years, Se has …

[HTML][HTML] Organic selenium compounds as potential chemotherapeutic agents for improved cancer treatment

V Gandin, P Khalkar, J Braude… - Free Radical Biology and …, 2018 - Elsevier
Selenium (Se)-containing compounds have attracted a growing interest as anticancer
agents over recent decades, with mounting reports demonstrating their high efficacy and …

Selenium compounds as novel potential anticancer agents

D Radomska, R Czarnomysy, D Radomski… - International Journal of …, 2021 - mdpi.com
The high number of new cancer incidences and the associated mortality continue to be
alarming, leading to the search for new therapies that would be more effective and less …

[HTML][HTML] Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents

E Domínguez-Álvarez, B Rácz, MA Marć… - Drug Resistance …, 2022 - Elsevier
Selenium is an essential trace element that is crucial for cellular antioxidant defense against
reactive oxygen species (ROS). Recently, many selenium-containing compounds have …

[HTML][HTML] Metal-and metalloid-based compounds to target and reverse cancer multidrug resistance

A Valente, A Podolski-Renić, I Poetsch… - Drug Resistance …, 2021 - Elsevier
Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …

Selenides and diselenides: A review of their anticancer and chemopreventive activity

M Álvarez-Pérez, W Ali, MA Marć, J Handzlik… - Molecules, 2018 - mdpi.com
Selenium and selenocompounds have attracted the attention and the efforts of scientists
worldwide due to their promising potential applications in cancer prevention and/or …

The innovative potential of selenium-containing agents for fighting cancer and viral infections

W Ali, R Benedetti, J Handzlik, C Zwergel… - Drug Discovery …, 2021 - Elsevier
Selenium-containing compounds have emerged as a potentially promising treatment for
viral infections and tumor development and dissemination. Selenium per se is often …

Organoselenium compounds as novel adjuvants of chemotherapy drugs—a promising approach to fight cancer drug resistance

G Spengler, M Gajdács, MA Marć… - Molecules, 2019 - mdpi.com
Malignant diseases present a serious public health burden and their treatment with
traditional chemotherapy cannot be considered an all-round solution, due to toxic side …

QSAR modeling and molecular docking studies of 2-oxo-1, 2-dihydroquinoline-4-carboxylic acid derivatives as p-glycoprotein inhibitors for combating cancer …

M Lahyaoui, A Diane, H El-Idrissi, T Saffaj, YK Rodi… - Heliyon, 2023 - cell.com
Multidrug resistance (MDR) proteins related to the ATP-binding cassette family are found in
a very wide range of human tumors and result in therapeutic failure. The overexpression of …

Selenium-containing polysaccharides—Structural diversity, biosynthesis, chemical modifications and biological activity

S Górska, A Maksymiuk, J Turło - Applied Sciences, 2021 - mdpi.com
Selenosugars are a group of sugar derivatives of great structural diversity (eg, molar
masses, selenium oxidation state, and selenium binding), obtained as a result of …