Immune ageing at single-cell resolution

DA Mogilenko, I Shchukina, MN Artyomov - Nature Reviews …, 2022 - nature.com
Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

COVID-19 pathophysiology: A review

K Yuki, M Fujiogi, S Koutsogiannaki - Clinical immunology, 2020 - Elsevier
In December 2019, a novel coronavirus, now named as SARS-CoV-2, caused a series of
acute atypical respiratory diseases in Wuhan, Hubei Province, China. The disease caused …

Cytokine storm in COVID-19—immunopathological mechanisms, clinical considerations, and therapeutic approaches: the REPROGRAM consortium position paper

S Bhaskar, A Sinha, M Banach, S Mittoo… - Frontiers in …, 2020 - frontiersin.org
Cytokine storm is an acute hyperinflammatory response that may be responsible for critical
illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure …

Immunosenescence: a key player in cancer development

J Lian, Y Yue, W Yu, Y Zhang - Journal of hematology & oncology, 2020 - Springer
Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

Immunosenescence, aging and successful aging

Y Wang, C Dong, Y Han, Z Gu, C Sun - Frontiers in immunology, 2022 - frontiersin.org
Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …

[HTML][HTML] In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

NAP Lieberman, V Peddu, H Xie, L Shrestha… - PLoS …, 2020 - journals.plos.org
Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has shown a wide range of clinical manifestations in different patient populations …

CAR-T cell performance: how to improve their persistence?

G López-Cantillo, C Urueña, BA Camacho… - Frontiers in …, 2022 - frontiersin.org
Adoptive cell therapy with T cells reprogrammed to express chimeric antigen receptors (CAR-
T cells) has been highly successful in patients with hematological neoplasms. However, its …

Connecting aging biology and inflammation in the omics era

KA Walker, N Basisty, DM Wilson… - The Journal of Clinical …, 2022 - Am Soc Clin Investig
Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …

Age-associated remodeling of T cell immunity and metabolism

SJ Han, P Georgiev, AE Ringel, AH Sharpe, MC Haigis - Cell metabolism, 2023 - cell.com
Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …