Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors
have successfully improved outcomes in several tumor types. In addition, currently, immune …

Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs)
play important roles in cancer progression. Here, we have characterized the ontogeny and …

Hepatocellular carcinoma (HCC) is a cancer of substantial morphologic, genetic and
phenotypic diversity. Yet we do not understand the relationship between intratumor …

Clear cell renal cell carcinoma (ccRCC) is a common kidney malignancy characterized by a
poor prognosis. Suppressor of variegation 3–9 homolog 1 (SUV39H1), which encodes a …

There are unmet clinical needs for novel therapeutic targets and drugs for bladder cancer.
Majority of previous work relied on limited bladder cancer cell lines, which could not well …

Bladder cancer (BC) is a complex and highly heterogeneous stem cell disease associated
with high morbidity and mortality rates if it is not treated properly. Early diagnosis with …

Mitochondrial serine hydroxymethyltransferase (SHMT2) catalyzes the conversion of serine
to glycine and concomitantly produces one-carbon units to support cell growth and is …

Effective cancer therapy requires identification of signaling networks and investigating their
potential role in proliferation and invasion of cancer cells. Among molecular pathways …

Arsenic and benzo [a] pyrene (BaP) are among the most common environmental
carcinogens causing lung cancer. Millions of people are exposed to arsenic through …