Genetic and genomic techniques have proven incredibly powerful for identifying and
studying molecular players implicated in the epigenetic regulation of DNA-templated …

Rather than a “short‐term tenant,” the tumor microbiome has been shown to play a vital role
as a “permanent resident,” affecting carcinogenesis, cancer development, metastasis, and …

Lysine l-lactylation (Kl-la) is a novel protein posttranslational modification (PTM) driven by l-
lactate. This PTM has three isomers: Kl-la, N-ε-(carboxyethyl)-lysine (Kce) and d-lactyl-lysine …

Mutations of the androgen receptor (AR) associated with prostate cancer and androgen
insensitivity syndrome may profoundly influence its structure, protein interaction network …

Post-translational modifications (PTMs) alter protein structure, function, and localization and
play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from …

Thiolactones are often described as latent thiols. They can be ring-opened by hydroxy or
amine groups releasing thiols, which can further react with a large variety of functional …

In the past decade, we have seen the emergence of sequence-based methods to
understand chromosome organization. With the confluence of in situ approaches to capture …

Aging results from the accumulation of molecular damage that impairs normal biochemical
processes. We previously reported that age‐linked damage to amino acid sequence NGR …

Cancer cells undergo metabolic reprogramming to rely mostly on aerobic glycolysis (the
Warburg effect). The increased glycolytic intake enhances the intracellular levels of reactive …

From attributing mutations to cancers with the advent of cutting-edge genetic technology in
recent decades, to re-searching the age-old theory of intrinsic metabolic shift of cancers …