The heart's extraordinary metabolic flexibility allows it to adapt to normal changes in
physiology in order to preserve its function. Alterations in the metabolic profile of the heart …

The shift in substrate preference away from fatty acid oxidation (FAO) towards increased
glucose utilization in heart failure has long been interpreted as an oxygen-sparing …

Even in healthy aging, cardiac morbidity and mortality increase with age in both mice and
humans. These effects include a decline in diastolic function, left ventricular hypertrophy …

Hypertrophic cardiomyopathy (HCM) is a well-established risk factor for cardiovascular
mortality worldwide. Although hypertrophy is traditionally regarded as an adaptive response …

Background Alcohol consumption has been shown to disrupt hepatic lipid homeostasis.
Long-chain acyl-CoA synthetase 1 (ACSL1) critically regulates hepatic fatty acid metabolism …

Cardiac hypertrophy is closely linked to impaired fatty acid oxidation, but the molecular basis
of this link is unclear. Here, we investigated the loss of an obligate enzyme in mitochondrial …

Aim Diastolic dysfunction is the decreased flexibility of the left ventricle due to the impaired
ability of the myocardium to relax and plays an important role in the pathogenesis of heart …

Each individual cell-type is defined by its distinct morphology, phenotype, molecular and
lipidomic profile. The importance of maintaining cell-specific lipidomic profiles is exemplified …

Simple Summary The leopard coralgrouper (Plectropomus leopardus) is highly valuable in
the ornamental fish market owing to its bright red color. Astaxanthin is commonly used as a …

Long-chain fatty acid oxidation is frequently impaired in primary and systemic metabolic
diseases affecting the heart; thus, therapeutically increasing reliance on normally minor …