Brain-derived neurotrophic factor (BDNF)—a member of a small family of secreted proteins
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal
and differentiation. In order to better understand the contribution of substrate stiffness to …

While limited research is available, evidence indicates that physical and mental activity
influence the aging process. Human data show that executive functions of the type …

Abstract Doublecortin (DCX), a microtubule‐associated phosphoprotein, has been recently
utilized as a marker of newly born neurons in the adult dentate gyrus (DG). Nonetheless, it is …

Here we present a protocol for extraction and culture of neurons from adult rat or mouse
CNS. The method proscribes an optimized protease digestion of slices, control of osmolarity …

The adult brain contains small populations of neural precursor cells (NPC) that can give rise
to new neurons and glia, and may play important roles in learning and memory, and …

The adult mammalian brain contains a population of neural stem cells that can give rise to
neurons, astrocytes, and oligodendrocytes and are thought to be involved in certain forms of …

The formation of new neurons in the adult central nervous system (CNS) has been
recognized as one of the major findings in neuroanatomical research. The hippocampal …

The cerebellum is critical for motor coordination and cognitive function and is the target of
transformation in medulloblastoma, the most common malignant brain tumor in children …