Contrast agents for molecular photoacoustic imaging

J Weber, PC Beard, SE Bohndiek - Nature methods, 2016 - nature.com
Photoacoustic imaging (PAI) is an emerging tool that bridges the traditional depth limits of
ballistic optical imaging and the resolution limits of diffuse optical imaging. Using the …

Nanobodies as therapeutics: big opportunities for small antibodies

S Steeland, RE Vandenbroucke, C Libert - Drug discovery today, 2016 - Elsevier
Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

M Agrawal, DK Tripathi, S Saraf, S Saraf… - Journal of controlled …, 2017 - Elsevier
In this modern era, with the help of various advanced technologies, medical science has
overcome most of the health-related issues successfully. Though, some diseases still remain …

A molecular imaging primer: modalities, imaging agents, and applications

ML James, SS Gambhir - Physiological reviews, 2012 - journals.physiology.org
Molecular imaging is revolutionizing the way we study the inner workings of the human
body, diagnose diseases, approach drug design, and assess therapies. The field as a whole …

An effective immuno-PET imaging method to monitor CD8-dependent responses to immunotherapy

R Tavaré, H Escuin-Ordinas, S Mok, MN McCracken… - Cancer research, 2016 - AACR
The rapidly advancing field of cancer immunotherapy is currently limited by the scarcity of
noninvasive and quantitative technologies capable of monitoring the presence and …

Molecular imaging of the tumor microenvironment

Z Zhou, ZR Lu - Advanced Drug Delivery Reviews, 2017 - Elsevier
The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …

HER2-directed antibodies, affibodies and nanobodies as drug-delivery vehicles in breast cancer with a specific focus on radioimmunotherapy and …

B Altunay, A Morgenroth, M Beheshti, A Vogg… - European journal of …, 2021 - Springer
Purpose The aim of the present paper is to review the role of HER2 antibodies, affibodies
and nanobodies as vehicles for imaging and therapy approaches in breast cancer, including …

[HTML][HTML] Nanobody: the “magic bullet” for molecular imaging?

R Chakravarty, S Goel, W Cai - Theranostics, 2014 - ncbi.nlm.nih.gov
Molecular imaging involves the non-invasive investigation of biological processes in vivo at
the cellular and molecular level, which can play diverse roles in better understanding and …

In vivo imaging with antibodies and engineered fragments

AC Freise, AM Wu - Molecular immunology, 2015 - Elsevier
Antibodies have clearly demonstrated their utility as therapeutics, providing highly selective
and effective drugs to treat diseases in oncology, hematology, cardiology, immunology and …

Optical image-guided cancer surgery: challenges and limitations

S Keereweer, PBAA Van Driel, TJA Snoeks… - Clinical Cancer …, 2013 - AACR
Optical image-guided cancer surgery is a promising technique to adequately determine
tumor margins by tumor-specific targeting, potentially resulting in complete resection of …