In situ gelling formulations are drug delivery systems which typically exist in a liquid form at
room temperature and change into gel state after application to the body in response to …

In situ gelling drug delivery systems have gained enormous attention over the last decade.
They are in a sol-state before administration, and they are capable of forming gels in …

Blindness and vision impairment are the most devastating global health problems resulting
in a substantial economic and social burden. Delivery of drug to particular parts of the …

This review highlights how hydrogel formulations can improve intravitreal protein delivery to
the posterior segment of the eye in order to increase therapeutic outcome and patient …

Ocular drug delivery is a significantly challenging task due to the presence of various
anatomical and physiological barriers in the eye. Naturally available polysaccharides, when …

The major complications associated with the administration of ocular dosage forms are the
precorneal loss due to the nasolacrimal drainage and high turnover of tear fluid. In situ …

Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye
drops because they associate the advantages of solutions such as accuracy and …

The main inconvenience of conventional eye drops is the rapid washout of the drugs due to
nasolacrimal drainage or ophthalmic barriers. The ocular drug bioavailability can be …

Abstract Poloxamer 407 (P407) is widely used for targeted drug-delivery because it exhibits
thermoresponsive gelation behavior near body temperature, stemming from a disorder-to …

The present study was focused on the development of doxycycline niosomal
thermosensitive in situ gel for ophthalmic application. For this purpose, in situ gel …