Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …

Autophagy represents an intracellular degradation process which is involved in both cellular
homeostasis and disease settings. In the last two decades, the molecular machinery …

Autophagy is a self-degradation pathway, in which cytoplasmic material is sequestered in
double-membrane vesicles and delivered to the lysosome for degradation. Under basal …

Phosphatidylinositol 3‐phosphate (PtdIns3P) is generated on the cytosolic leaflet of cellular
membranes, primarily by phosphorylation of phosphatidylinositol by class II and class III …

Abstract The Endosomal Sorting Complex Required for Transport (ESCRT) proteins form an
evolutionarily conserved membrane remodelling machinery. Identified originally for their role …

During the final stage of cell division, cytokinesis, the Aurora-B-dependent abscission
checkpoint (NoCut) delays membrane abscission to avoid DNA damage and aneuploidy in …

Abstract Adaptor proteins (AP 1–5) are heterotetrameric complexes that facilitate specialized
cargo sorting in vesicular-mediated trafficking. Mutations in AP5Z1, encoding a subunit of …

Phosphoinositides are low abundant but essential phospholipids in eukaryotic cells and
refer to phosphatidylinositol and its seven polyphospho-derivatives. In this review, we …

ABSTRACT ZFYVE26/Spastizin and SPG11/Spatacsin encode 2 large proteins that are
mutated in hereditary autosomal-recessive spastic paraplegia/paraparesis (HSP) type 15 …

Hereditary spastic paraparesis type 15 is a recessive complicated form of the disease
clinically characterized by slowly progressive spastic paraparesis and mental deterioration …