Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Ischemic stroke and Alzheimer's disease (AD), despite being distinct disease entities, share
numerous pathophysiological mechanisms such as those mediated by inflammation …

The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) is a key Ras
activator that is autoinhibited in the cytosol and activates upon membrane recruitment …

The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …

The dynamics of enzymes are directly associated with their functions in various biological
processes. Nevertheless, the ability to image motions of single enzymes in a highly parallel …

Protein kinase C (PKC) is a family of Ser/Thr kinases that regulate a multitude of cellular
processes through participation in the phosphoinositide signaling pathway. Significant …

In chemotaxing ameboid cells, a complex leading-edge signaling circuit forms on the
cytoplasmic leaflet of the plasma membrane and directs both actin and membrane …

PKC comprises a large family of serine/threonine kinases that share a requirement for
allosteric activation by lipids. While PKC isoforms have significant homology, functional …

The transformation of molecular binding events into cellular decisions is the basis of most
biological signal transduction. A fundamental challenge faced by these systems is that …

Lipid/cholesterol mixtures derived from cell membranes as well as their synthetic
reconstitutions exhibit well-defined miscibility phase transitions and critical phenomena near …