[HTML][HTML] Cell Membrane Sialome: Sialic Acids as Therapeutic Targets and Regulators of Drug Resistance in Human Cancer Management
P Jastrząb, K Narejko, H Car, P Wielgat - Cancers, 2023 - mdpi.com
Simple Summary The aberrant sialylation of membrane glycocalyx plays a pivotal role in the
regulation of malignant cell behavior and correlates with a worse prognosis and shorter …
regulation of malignant cell behavior and correlates with a worse prognosis and shorter …
[HTML][HTML] Sialic acid blockade inhibits the metastatic spread of prostate cancer to bone
K Hodgson, M Orozco-Moreno, EA Goode, M Fisher… - …, 2024 - thelancet.com
Background Bone metastasis is a common consequence of advanced prostate cancer.
Bisphosphonates can be used to manage symptoms, but there are currently no curative …
Bisphosphonates can be used to manage symptoms, but there are currently no curative …
Pharmacological suppression of HHLA2 glycosylation restores anti-tumor immunity in colorectal cancer
D Zhang, J Xie, F Sun, R Xu, W Liu, J Xu, X Huang… - Cancer Letters, 2024 - Elsevier
Immunotherapy aimed at inhibiting the negative co-stimulatory molecule programmed cell
death-ligand 1 (PD-L1) has limited effectiveness, with clinical response rates remaining …
death-ligand 1 (PD-L1) has limited effectiveness, with clinical response rates remaining …
[HTML][HTML] Sialylation Inhibition Can Partially Revert Acquired Resistance to Enzalutamide in Prostate Cancer Cells
EA Goode, M Orozco-Moreno, K Hodgson… - …, 2024 - pmc.ncbi.nlm.nih.gov
Prostate cancer is a lethal solid malignancy and a leading cause of cancer-related deaths in
males worldwide. Treatments, including radical prostatectomy, radiotherapy, and hormone …
males worldwide. Treatments, including radical prostatectomy, radiotherapy, and hormone …
[HTML][HTML] Fucosyltransferase 3 and 8 promote the metastatic capacity of cancer stem-like cells via CD15s and E-cadherin in esophageal cancer
AR Abookheili, J Asadi, A Khosravi… - Iranian Journal of Basic …, 2024 - pmc.ncbi.nlm.nih.gov
Objective (s): Esophageal cancer stem cells (ECSCs) have been identified as the subset of
cells within esophageal squamous cell carcinoma that possess tumorigenic, invasive, and …
cells within esophageal squamous cell carcinoma that possess tumorigenic, invasive, and …
The glycosylation landscape of prostate cancer tissues and biofluids
An overview of the role of glycosylation in prostate cancer (PCa) development and
progression is presented, focusing on recent advancements in defining the N-glycome …
progression is presented, focusing on recent advancements in defining the N-glycome …