Rotavirus is a major pathogen of infantile gastroenteritis. It is a large and complex virus with
a multilayered capsid organization that integrates the deter minants of host specificity, cell …

The rotaviruses, members of the family Reoviridae, are icosahedral triple-layered viruses
with genomes consisting of 11 segments of double-stranded (ds) RNA. A characteristic …

Gastroenteritis is among the leading causes of mortality globally in infants and young
children, with rotavirus (RV) causing~ 258 million episodes of diarrhea and~ 128,000 deaths …

In rotavirus-infected cells, the non-structural proteins NSP5 and NSP2 localize in complexes
called viroplasms, where replication and assembly occur. Recently, we have demonstrated …

Viroplasms are discrete structures formed in the cytoplasm of rotavirus-infected cells and
constitute the replication machinery of the virus. The non-structural proteins NSP2 and NSP5 …

The nonstructural protein NSP2 is a component of rotavirus replication intermediates and
accumulates in cytoplasmic inclusions (viroplasms), sites of genome RNA replication and …

Rotaviruses, nonenveloped viruses presenting a distinctive triple-layered particle
architecture enclosing a segmented double-stranded RNA genome, exhibit a unique …

The nonstructural protein NS5A of hepatitis c virus (HCV) has been demonstrated to be a
phosphoprotein with an apparent molecular mass of 56 kDa. In the presence of other viral …

Rotavirus (RV) replicates in round-shaped cytoplasmic viral factories, although how they
assemble remains unknown. During RV infection, NSP5 undergoes hyperphosphorylation …

Rotavirus genomes contain 11 double-stranded (ds) RNA segments. Genome segment 11
encodes the non-structural protein NSP5 and, in some strains, also NSP6. NSP5 is …