The sliding clamp PCNA is a multifunctional homotrimer mainly linked to DNA replication.
During this process, cells must ensure an accurate and complete genome replication when …

The impact of invasive fungal infections on human health is a serious, but largely
overlooked, public health issue. Commonly affecting the immunocompromised community …

The human sliding clamp, Proliferating Cell Nuclear Antigen (hPCNA), interacts with over
200 proteins through a conserved binding motif, the PIP-box, to orchestrate DNA replication …

Eukaryotic proliferating cell nuclear antigen (PCNA) plays an essential role in orchestrating
the assembly of the replisome complex, stimulating processive DNA synthesis, and …

Human proliferating cell nuclear antigen (PCNA) is a critical mediator of DNA replication and
repair, acting as a docking platform for replication proteins. Disrupting these interactions with …

Tartaric acid has high economic value as an antioxidant and flavorant in food and wine
industries. l-Tartaric acid biosynthesis in wine grape (Vitis vinifera) uses ascorbic acid …

Human proliferating cell nuclear antigen (hPCNA) is a DNA replication processivity factor,
which acts as a docking platform, allowing proteins to have access to the replication fork and …

DNA polymerase δ (Pol δ) is a key enzyme for the maintenance of genome integrity in
eukaryotic cells, acting in concert with the sliding clamp processivity factor PCNA …

Invasive fungal infections (IFIs) are prevalent in immunocompromised patients. Due to
alarming levels of increasing resistance in clinical settings, new drugs targeting the major …

An assembly of multiprotein complexes achieves chromosomal DNA replication at the
replication fork. In eukaryotes, proliferating cell nuclear antigen (PCNA) plays a vital role in …