Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex
region (MHC) significantly affect the risk of various diseases, especially autoimmune …

In inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis
(UC), the immune system relentlessly attacks intestinal cells, causing recurrent tissue …

Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve …

Objective One of the current hypotheses to explain the proinflammatory immune response in
IBD is a dysregulated T cell reaction to yet unknown intestinal antigens. As such, it may be …

The human leukocyte antigen (HLA) region on chromosome 6 is strongly associated with
many immune-mediated and infection-related diseases. Due to its highly polymorphic nature …

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with abdominal pain,
diarrhea, and mucopurulent stools as the main symptoms. Its incidence is increasing …

Autoimmune neurological syndromes (AINS) with autoantibodies against the 65 kDa isoform
of the glutamic acid decarboxylase (GAD65) present with limbic encephalitis, including …

Variation within the non-coding genome may influence the regulation and expression of
important genes involved in immune control such as the human leukocyte antigen (HLA) …

The SNP‐HLA Reference Consortium (SHLARC), a component of the 18th International
HLA and Immunogenetics Workshop, is aimed at collecting diverse and extensive human …

Background Sex is an integral variable often overlooked in complex disease genetics.
Differences between sexes have been reported in natural history, disease complications …