Reactive oxygen species (ROS) are metabolic byproducts that are necessary for
physiological function but can be toxic at high levels. Levels of these oxidative stressors …

Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological
hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β‐amyloid …

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that affects more
than 44 million people worldwide. Despite the high disease burden, there is no effective …

The amyloid hypothesis has driven drug development strategies for Alzheimer's disease for
over 20 years. We review why accumulation of amyloid-beta (Aβ) oligomers is generally …

A hallmark of Alzheimer's disease (AD) is the aggregation of β-amyloid peptides (Aβ) into
amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the …

Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …

Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has
arisen from the application of molecular and cell biology to this complex disorder of the …

Aβ1–42 is a self-associating peptide whose neurotoxic derivatives are thought to play a role
in Alzheimer's pathogenesis. Neurotoxicity of amyloid β protein (Aβ) has been attributed to …

There has been a growing need for in vitro models of neurodegenerative diseases such as
Alzheimer's disease that would enable a better understanding of etiology and faster …