Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

The efficacy of adoptive T-cell therapies largely depends on the generation of T-cell
populations that provide rapid effector function and long-term protective immunity. Yet it is …

Exosomes and extracellular nanovesicles (NV) derived from mesenchymal stem cells (MSC)
may be used for the treatment of ischemic stroke owing to their multifaceted therapeutic …

Many infections and stress signals can rapidly activate the NLRP3 inflammasome to elicit
robust inflammatory responses. This activation requires a priming step, which is thought to …

Interruption of iron homeostasis is correlated with cell ferroptosis and degenerative
diseases. Nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy has been …

Terpenoids are the largest class of natural products, most of which are derived from plants.
Amongst their numerous biological properties, their anti-tumor effects are of interest for they …

The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a
subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide …

Ethnopharmacological relevance Plant essential oils (PEOs) extracted from aromatic
compounds of the plant contain complex mixtures of volatile and lipophilic bioactive …

The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …