Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
and amyotrophic lateral sclerosis (ALS) lack robust diagnostics and prognostic biomarkers …

Alzheimer's disease (AD), a progressive neurodegenerative disorder, lacks preclinical
diagnostic biomarkers and therapeutic drugs. Thus, earlier intervention in AD is a top …

Background Status epilepticus (SE) as a severe neurodegenerative disease, greatly
negatively affects people's health, and there is an urgent need for innovative treatments. The …

Glutamate is the major excitatory neurotransmitter in the nervous system, where it induces
multiple beneficial and essential effects. Yet, excess glutamate, evident in a kaleidoscope of …

Much work has been carried out in recent years showing that elevated glutamate levels in
the extracellular environment of the central nervous system play a pivotal role in …

The advent of epigenetics brought in a tectonic shift in the understanding of molecular basis
of complex diseases like ischemic stroke (IS). Substantial scientific inquiry into the …

There is mounting evidence that oxidative glucose metabolism is impaired in epilepsy and
recent work has further characterized the metabolic mechanisms involved. In healthy people …

In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar
Audiogenic Rat (WAR), first introduced to the neuroscience international community more …