Since diabetes is becoming a global epidemic, there is a great need to develop early β-cell
specific diagnostic techniques for this disorder. There are two types of diabetes (ie, type 1 …

For more than a decade, researchers have been trying to develop non-invasive imaging
techniques for the in vivo measurement of viable pancreatic beta cells. However, in spite of …

Loss of β-cell function in type 1 and type 2 diabetes leads to metabolic dysregulation and
inability to maintain normoglycemia. Noninvasive imaging of β-cell function in vivo would …

A microfluidic islet perifusion device was developed for the assessment of dynamic insulin
secretion of multiple pancreatic islets and simultaneous fluorescence imaging of calcium …

The noninvasive measurement of functional β-cell mass would be clinically valuable for
monitoring the progression of type 1 and type 2 diabetes as well as the viability of …

Purpose We developed a mouse model that enables non-invasive assessment of changes
in β cell mass. Procedures We generated a transgenic mouse expressing luciferase under …

Insulin-dependent (type 1) diabetes mellitus is a metabolic disease with a complex
multifactorial etiology and a poorly understood pathogenesis. Genetic and environmental …

AIM: Restoration of long-term normal blood glucose control in diabetic patients supports the
elaboration of an artificial beta cell. The possibility of implantation of the three crucial …

Although type 1 diabetes cannot be prevented or reversed, replacement of insulin
production by transplantation of the pancreas or pancreatic islets represents a definitive …

Purpose Manganese ion has been extensively used as a magnetic resonance imaging
(MRI) contrast agent in preclinical studies to assess tissue anatomy, function, and neuronal …