The role of mitochondria in the mechanisms of cardiac ischemia-reperfusion injury

AV Kuznetsov, S Javadov, R Margreiter, M Grimm… - Antioxidants, 2019 - mdpi.com
Mitochondria play a critical role in maintaining cellular function by ATP production. They are
also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of …

An emerging role for tubulin isotypes in modulating cancer biology and chemotherapy resistance

AL Parker, WS Teo, JA McCarroll… - International journal of …, 2017 - mdpi.com
Tubulin proteins, as components of the microtubule cytoskeleton perform critical cellular
functions throughout all phases of the cell cycle. Altered tubulin isotype composition of …

[HTML][HTML] H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation

AV Kuznetsov, S Javadov, S Sickinger… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Dysfunction of cardiac energy metabolism plays a critical role in many cardiac diseases,
including heart failure, myocardial infarction and ischemia–reperfusion injury and organ …

The role of voltage-dependent anion channel in mitochondrial dysfunction and human disease

JT Varughese, SK Buchanan, AS Pitt - Cells, 2021 - mdpi.com
The voltage-dependent anion channel (VDAC) is a β-barrel membrane protein located in the
outer mitochondrial membrane (OMM). VDAC has two conductance states: an open anion …

Crosstalk between mitochondria and cytoskeleton in cardiac cells

AV Kuznetsov, S Javadov, M Grimm, R Margreiter… - Cells, 2020 - mdpi.com
Elucidation of the mitochondrial regulatory mechanisms for the understanding of muscle
bioenergetics and the role of mitochondria is a fundamental problem in cellular physiology …

Mitochondrial bioenergetic dysfunction in the D2.mdx model of Duchenne muscular dystrophy is associated with microtubule disorganization in skeletal muscle

SV Ramos, MC Hughes, LJ Delfinis, CA Bellissimo… - PLoS …, 2020 - journals.plos.org
In Duchenne muscular dystrophy, a lack of dystrophin leads to extensive muscle weakness
and atrophy that is linked to cellular metabolic dysfunction and oxidative stress. This …

[HTML][HTML] Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome

R Guzun, M Gonzalez-Granillo… - … et Biophysica Acta (BBA …, 2012 - Elsevier
This review describes the recent experimental data on the importance of the VDAC–
cytoskeleton interactions in determining the mechanisms of energy and metabolite transfer …

[Retracted] Tongyang Huoxue Decoction (TYHX) Ameliorating Hypoxia/Reoxygenation‐Induced Disequilibrium of Calcium Homeostasis and Redox Imbalance via …

X Chang, S Yao, Q Wu, Y Wang… - Oxidative Medicine and …, 2021 - Wiley Online Library
Sick sinus syndrome (SSS) is a disease with bradycardia or arrhythmia. The pathological
mechanism of SSS is mainly due to the abnormal conduction function of the sinoatrial node …

The interconnections between the microtubules and mitochondrial networks in cardiocerebrovascular diseases: implications for therapy

X Shi, X Jiang, C Chen, Y Zhang, X Sun - Pharmacological Research, 2022 - Elsevier
Microtubules, a highly dynamic cytoskeleton, participate in many cellular activities including
mechanical support, organelles interactions, and intracellular trafficking. Microtubule …

[HTML][HTML] Metabolic remodeling in human colorectal cancer and surrounding tissues: Alterations in regulation of mitochondrial respiration and metabolic fluxes

V Chekulayev, K Mado, I Shevchuk, A Koit… - … and biophysics reports, 2015 - Elsevier
The aim of the work was to evaluate whether or not there is glycolytic reprogramming in the
neighboring cells of colorectal cancer (CRC). Using postoperative material we have …