The ubiquitous RNA-binding protein, Hfq, has been shown to be required for the fitness and
virulence of an increasing number of bacterial pathogens. Mutants lacking Hfq are often …

Bacterial chitinases (EC 3.2. 1.14) and chitin-binding proteins (CBPs) play a fundamental
role in the degradation of the ubiquitous biopolymer chitin, and the degradation products …

Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-
resistance among pathogenic microorganisms. The need to overcome these deficiencies …

Bacteria are often exposed to a hostile environment and have developed a plethora of
cellular processes in order to survive. A burgeoning list of small non-coding RNAs (sRNAs) …

Most of the sequenced bacterial genomes contain a gene encoding a protein known as Hfq
that resembles the eukaryotic RNA-binding proteins of the LSm family. It was originally …

Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

Francisella tularensis is a highly virulent gram-negative intracellular bacterium that causes
the zoonotic disease tularemia. Essential for its virulence is the ability to multiply within host …

Antibiotic translocation across membranes of Gram-negative bacteria is a key step for the
activity on their specific intracellular targets. Resistant bacteria control their membrane …

Many pathogenic intracellular bacteria manipulate the host phago-endosomal system to
establish and maintain a permissive niche. The fate and identity of these intracellular …

Francisella tularensis is a highly-infectious bacterium that causes the rapid, and often lethal
disease, tularemia. Many studies have been performed to identify and characterize the …