RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Ubiquitous in eukaryotes, circular RNAs (circRNAs) comprise a large class of mostly non-
coding RNAs produced by back-splicing. Although some circRNAs have demonstrated …

The RNA‐binding proteins encoded by the highly conserved elav/Hu gene family, found in
all metazoans, regulate the expression of a wide range of genes, at both the co …

One gene does not equal one RNA or protein. The genomic revolution has revealed
numerous different RNA and protein molecules that can be produced from one gene, such …

Most eukaryotic genes undergo alternative splicing (AS), but the overall functional
significance of this process remains a controversial issue. It has been noticed that the …

Maturation of eukaryotic pre-mRNAs via splicing and polyadenylation is modulated across
cell types and conditions by a variety of RNA-binding proteins (RBPs). Although there exist …

Alternative polyadenylation (APA) generates transcript isoforms that differ in the position of
the 3′ cleavage site, resulting in the production of mRNA isoforms with different length 3 …

In many species highly expressed genes (HEGs) over-employ the synonymous codons that
match the more abundant iso-acceptor tRNAs. Bacterial transgene codon randomization …

Alternative translation initiation (ATLI) refers to the existence of multiple translation initiation
sites per gene and is a widespread phenomenon in eukaryotes. ATLI is commonly assumed …